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NCT05250037 · ClinicalTrials.gov registry record

The Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Cell Transplantation (The RV-BOS Study)

A clinical trial of Hematopoietic and Lymphoid Cell Neoplasm and Bronchiolitis Obliterans Syndrome, sponsored by Fred Hutchinson Cancer Center.

Recruiting
Registry status
250
Enrollment target
4
Study locations

NCT05250037 is a study of Hematopoietic and Lymphoid Cell Neoplasm and Bronchiolitis Obliterans Syndrome that is actively recruiting participants, run by Fred Hutchinson Cancer Center. The registered enrollment target is 250 participants, below the 951-participant average among 104 other Hematopoietic and Lymphoid Cell Neoplasm trials with a reported enrollment target (74% lower). The trial reports 4 study locations across 4 states.

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The verdict

NCT05250037, a study of Hematopoietic and Lymphoid Cell Neoplasm and Bronchiolitis Obliterans Syndrome, is actively recruiting participants, sponsored by Fred Hutchinson Cancer Center.

RECRUITING
Registry status
250 participants
Enrollment target
4
Study locations

Study Summary

This observational trial studies whether respiratory viruses are the cause of lung disease (bronchiolitis obliterans syndrome \[BOS\] or graft-versus-host disease of the lung) and changes in lung function in patients who have received a donor stem cell transplant. Patients with chronic graft-versus-host disease (cGVHD) are at higher risk of developing BOS. Studies have also shown that patients who had a respiratory viral illness early after their transplant are at higher risk of developing lung problems later on. Patients who are at risk and who already have BOS might benefit from being monitored more closely. Spirometry is a way of assessing a patient's lung function and is often used to diagnose lung disease. Spirometry measured at home with a simple handheld device may reduce the burden of performing pulmonary function testing at a facility and potentially help patients get their lung disease diagnosed and treated sooner.

Conditions Studied

Hematopoietic and Lymphoid Cell Neoplasm Bronchiolitis Obliterans Syndrome

Interventions

  • PROCEDURE Biospecimen Collection
  • OTHER Questionnaire Administration
  • PROCEDURE Home spirometry

Study Locations (4)

California

  • Stanford Cancer Institute - Palo Alto

Michigan

  • University of Michigan Cancer Center - Ann Arbor

Texas

  • MD Anderson Cancer Center - Houston

Washington

  • Fred Hutch/University of Washington Cancer Consortium - Seattle

Trial Details

FieldValue
Enrollment Target 250 participants
Start Date 2022-03-30
Est. Completion 2028-06-30

Sponsor

Fred Hutchinson Cancer Center

483 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05250037

The ClinicalTrials.gov registry entry for NCT05250037 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 951-participant average among 104 other Hematopoietic and Lymphoid Cell Neoplasm trials with a reported enrollment target (74% lower). The listed sponsor is Fred Hutchinson Cancer Center, which has 483 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Hematopoietic and Lymphoid Cell Neoplasm appearing as the primary indexed condition, and to 3 interventions - of which Biospecimen Collection is the first listed.

NCT05250037 reports 4 study locations spanning 4 distinct geographic areas - top geographies include California, Michigan, Texas.

Frequently Asked Questions

What is clinical trial NCT05250037 about?

NCT05250037 is a clinical study titled "The Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Cell Transplantation (The RV-BOS Study)". This observational trial studies whether respiratory viruses are the cause of lung disease (bronchiolitis obliterans syndrome \[BOS\] or graft-versus-host disease of the lung) and changes in lung function in patients who have received a donor stem cell transplant. Patients with chronic graft-versus-...

What is the current status of trial NCT05250037?

This trial is currently recruiting. The enrollment target is 250 participants. The study started on 2022-03-30. Estimated completion is 2028-06-30.

What conditions does trial NCT05250037 study?

This clinical trial studies the following conditions: Hematopoietic and Lymphoid Cell Neoplasm, Bronchiolitis Obliterans Syndrome.

What interventions are being tested in trial NCT05250037?

The interventions under investigation include: Biospecimen Collection (PROCEDURE), Questionnaire Administration (OTHER), Home spirometry (PROCEDURE).

Who is sponsoring clinical trial NCT05250037?

This trial is sponsored by Fred Hutchinson Cancer Center, which has 483 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05250037 being conducted?

This trial has 4 study locations across California, Michigan, Texas, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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