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NCT05233566 · ClinicalTrials.gov registry record · Phase 3
Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial
A Phase 3 study of Postoperative Depression, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- Phase 3
- Development phase
- 32
- Enrollment target
- 1
- Study location
NCT05233566: Completed Phase 3 study of Postoperative Depression, sponsored by Washington University School of Medicine.
NCT05233566 is a Phase 3 study of Postoperative Depression that has completed, run by Washington University School of Medicine. The registered enrollment target is 32 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05233566, a Phase 3 study of Postoperative Depression, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
This protocol describes a feasibility trial that will evaluate the feasibility of conducting a full-scale phase 3 trial testing the hypothesis that a postoperative sustained, low-dose ketamine infusion can prevent postoperative depressive symptoms when administered to a targeted population of neurosurgical patients with a history of depression.
Primary Outcome
The numerator will include all patients who are randomized to receive either ketamine or placebo. The denominator will include all patients who are approached by the research team to evaluated eligibility and offer consent.
Conditions Studied
Interventions
- DRUG Ketamine
- DRUG Normal saline
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2022-04-25 |
| Est. Completion | 2023-03-08 |
| Phase | Phase 3 |
What the finished NCT05233566 record still lists
NCT05233566 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Postoperative Depression appearing as the primary indexed condition, and to 2 interventions - of which Ketamine is the first listed.
NCT05233566 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT05233566 about?
NCT05233566 is a clinical study titled "Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial". This protocol describes a feasibility trial that will evaluate the feasibility of conducting a full-scale phase 3 trial testing the hypothesis that a postoperative sustained, low-dose ketamine infusion can prevent postoperative depressive symptoms when administered to a targeted population of neuros...
What is the current status of trial NCT05233566?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 32 participants. The study started on 2022-04-25. Estimated completion is 2023-03-08.
What conditions does trial NCT05233566 study?
This clinical trial studies the following conditions: Postoperative Depression.
What interventions are being tested in trial NCT05233566?
The interventions under investigation include: Ketamine (DRUG), Normal saline (DRUG).
Who is sponsoring clinical trial NCT05233566?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05233566 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05233566's enrollment target sits among peer trials
32 1909th of 2000 higher than 87 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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