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NCT05228457 · ClinicalTrials.gov registry record · NA
Intensive TMS for Bipolar Depression
A NA study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- NA
- Development phase
- 34
- Enrollment target
NCT05228457: Completed NA study, sponsored by University of Pennsylvania.
NCT05228457 is a NA study that has completed, run by University of Pennsylvania. The registered enrollment target is 34 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05228457, a NA study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
Study Summary
The research study is being conducted to test whether using high dose spaced theta-burst rTMS (a form of transcranial magnetic stimulation) produces a significant reduction in depressive symptoms compared with sham. This project will recruit patients aged 18-70 with symptoms of bipolar depression who have failed (or not shown signs of improvement) after at least two prior treatments.
Primary Outcome
The primary outcome will be based on the set of repeated Montgomery Asberg Depression scores (10 items rated on a 0-6 scale, 0-60 possible score range, with higher scores indicating greater depressive symptomology), obtained at baseline, on each of the five treatment days and post TMS.
Interventions
- DEVICE Intensive intermittent theta-burst stimulation (iTBS)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2022-03-01 |
| Est. Completion | 2024-02-19 |
| Phase | NA |
What the finished NCT05228457 record still lists
NCT05228457 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which Intensive intermittent theta-burst stimulation (iTBS) is the first listed.
NCT05228457 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05228457 about?
NCT05228457 is a clinical study titled "Intensive TMS for Bipolar Depression". The research study is being conducted to test whether using high dose spaced theta-burst rTMS (a form of transcranial magnetic stimulation) produces a significant reduction in depressive symptoms compared with sham. This project will recruit patients aged 18-70 with symptoms of bipolar depression wh...
What is the current status of trial NCT05228457?
This trial is currently completed. It is a NA study. The enrollment target is 34 participants. The study started on 2022-03-01. Estimated completion is 2024-02-19.
What interventions are being tested in trial NCT05228457?
The interventions under investigation include: Intensive intermittent theta-burst stimulation (iTBS) (DEVICE).
Who is sponsoring clinical trial NCT05228457?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05228457's enrollment target sits among peer trials
34 1570th of 2000 higher than 427 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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