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NCT05178888 · ClinicalTrials.gov registry record · Phase 1
Adagrasib in Combination With Palbociclib in Patients With Advanced Solid Tumors (KRYSTAL-16)
A Phase 1 study, sponsored by Mirati Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 11
- Enrollment target
NCT05178888: Completed Phase 1 study, sponsored by Mirati Therapeutics.
NCT05178888 is a Phase 1 study that has completed, run by Mirati Therapeutics. The registered enrollment target is 11 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (82% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05178888, a Phase 1 study, has completed, sponsored by Mirati Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 11 participants
- Enrollment target
Study Summary
This study will evaluate the safety and clinical activity of MRTX849 (adagrasib) in combination with palbociclib in patients with advanced solid tumor malignancies with KRAS G12C mutation.
Primary Outcome
Number of participants with treatment emergent adverse events
Interventions
- DRUG Palbociclib
- DRUG MRTX849
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2022-01-20 |
| Est. Completion | 2024-12-30 |
| Phase | Phase 1 |
What the finished NCT05178888 record still lists
NCT05178888 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 11 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (82% lower).
The record links to 0 conditions, and to 2 interventions - of which Palbociclib is the first listed.
NCT05178888 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05178888 about?
NCT05178888 is a clinical study titled "Adagrasib in Combination With Palbociclib in Patients With Advanced Solid Tumors (KRYSTAL-16)". This study will evaluate the safety and clinical activity of MRTX849 (adagrasib) in combination with palbociclib in patients with advanced solid tumor malignancies with KRAS G12C mutation.
What is the current status of trial NCT05178888?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 11 participants. The study started on 2022-01-20. Estimated completion is 2024-12-30.
What interventions are being tested in trial NCT05178888?
The interventions under investigation include: Palbociclib (DRUG), MRTX849 (DRUG).
Who is sponsoring clinical trial NCT05178888?
This trial is sponsored by Mirati Therapeutics, which has 49 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05178888's enrollment target sits among peer trials
11 1911th of 2000 higher than 88 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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