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NCT05178381 · ClinicalTrials.gov registry record · NA
Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults
A NA study of Healthy Aging, sponsored by University of Arizona.
- Completed
- Registry status
- NA
- Development phase
- 248
- Enrollment target
- 1
- Study location
NCT05178381 is a NA study of Healthy Aging that has completed, run by University of Arizona. The registered enrollment target is 248 participants, above the 115-participant average among 40 other Healthy Aging trials with a reported enrollment target (116% higher). The trial reports 1 study location across 1 state.
The verdict
NCT05178381, a NA study of Healthy Aging, has completed, sponsored by University of Arizona.
- COMPLETED
- Registry status
- NA
- Development phase
- 248 participants
- Enrollment target
- 1
- Study location
Study Summary
The full experiment involves participants coming into the lab on five separate occasions for neuropsychological testing, a decision making battery, functional and structural MRI, and two TMS sessions for stimulation of the target or control stimulation site. The clinical trial component concerns only the last two sessions where subjects will be randomly assigned to different groups to receive different TMS interventions. In particular, the TMS experiments will ask two main questions: 1. What is the causal role of frontal pole in explore-exploit behavior in younger and older adults? 2. What is the causal role of IFG in explore-exploit behavior in younger and older adults? The investigators will use continuous theta-burst transcranial magnetic stimulation (cTBS, Huang et al. 2005) to inhibit neural activity in each region for approximately 50 minutes (Wischnewski \& Schutter, 2015) and measure the downstream effects on behavior in younger and older adults. Consistent with their respective roles in the explore-exploit circuit (Figure 5 in Research Strategy), the investigators predict that inhibition of frontal pole will lead to a selective reduction in directed, but not random, exploration, while inhibition of IFG will decrease exploitation and lead to increases in both types of exploration. Participants in each age group will be pseudo-randomly assigned to either the frontal pole group or IFG group such that the study will have 42 participants (21 males, 21 females) in each group. Thus there will be four distinct groups of subjects older frontal pole, younger frontal pole, older IFG, younger IFG. Each participant will take part in two TMS sessions, one target and one control session. The order of sessions will be counterbalanced across subjects. The primary endpoints of the study are to determine whether: 1. cTBS applied to frontal pole inhibits directed exploration within the younger and older groups 2. cTBS applied to IFG promotes both directed and random expl
Conditions Studied
Interventions
- DEVICE Continuous theta burst transcranial magnetic stimulation
Study Locations (1)
Arizona
- University of Arizona - Tucson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 248 participants |
| Start Date | 2022-10-01 |
| Est. Completion | 2024-08-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05178381
The ClinicalTrials.gov registry entry for NCT05178381 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 248 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 115-participant average among 40 other Healthy Aging trials with a reported enrollment target (116% higher). The listed sponsor is University of Arizona, which has 349 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Healthy Aging appearing as the primary indexed condition, and to 1 intervention - of which Continuous theta burst transcranial magnetic stimulation is the first listed.
NCT05178381 reports 1 study location spanning 1 distinct geographic area - top geographies include Arizona.
Frequently Asked Questions
What is clinical trial NCT05178381 about?
NCT05178381 is a clinical study titled "Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults". The full experiment involves participants coming into the lab on five separate occasions for neuropsychological testing, a decision making battery, functional and structural MRI, and two TMS sessions for stimulation of the target or control stimulation site. The clinical trial component concerns onl...
What is the current status of trial NCT05178381?
This trial is currently completed. It is a NA study. The enrollment target is 248 participants. The study started on 2022-10-01. Estimated completion is 2024-08-01.
What conditions does trial NCT05178381 study?
This clinical trial studies the following conditions: Healthy Aging.
What interventions are being tested in trial NCT05178381?
The interventions under investigation include: Continuous theta burst transcranial magnetic stimulation (DEVICE).
Who is sponsoring clinical trial NCT05178381?
This trial is sponsored by University of Arizona, which has 349 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05178381 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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