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NCT05176379 · ClinicalTrials.gov registry record · Phase 4
Endothelial Derived Hyperpolarization Factor and Vascular Control
A Phase 4 study of Healthy, sponsored by University of Oklahoma.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT05176379: Recruiting Phase 4 study of Healthy, sponsored by University of Oklahoma.
NCT05176379 is a Phase 4 study of Healthy that is actively recruiting participants, run by University of Oklahoma. The registered enrollment target is 30 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05176379, a Phase 4 study of Healthy, is actively recruiting participants, sponsored by University of Oklahoma.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Most cardiometabolic diseases are characterized by increased muscle sympathetic nerve activity (MSNA) during rest and exercise which contributes to poor health outcomes. In healthy humans during muscle contraction, there is a blunting of skeletal muscle vascular responsiveness to increases in MSNA. However, the exact mechanisms involved are unknown although, best evidence suggests that the mechanism is endothelium derived, but nitric oxide (NO) and prostaglandin (PG) independent. Endothelium-derived hyperpolarizing factor (EDHF) is a NO and PG independent vasodilator in both cerebral and skeletal muscle circulations, however, it is unknown if EDHF contributes to vascular responsiveness during elevated MSNA. The application of lower body negative pressure (LBNP) is a safe and non-invasive manipulation that can be used to increase MSNA causing vasoconstriction in humans. Therefore, the purpose of this experiment is to determine if acute inhibition of EDHF alters central and peripheral vascular responses to LBNP at rest and during dynamic exercise. Thereby, providing evidence by which EDHF contributes to vascular control in healthy humans and identify it's potential as a therapeutic target for cardiometabolic diseases that are characterized by elevated MSNA
Conditions Studied
Interventions
- DRUG Fluconazole 150 mg
Study Locations (1)
Oklahoma
- Department of Health and Exercise Science - Norman
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2022-02-19 |
| Est. Completion | 2025-05 |
| Phase | Phase 4 |
What NCT05176379 shows while recruiting
NCT05176379 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 1 intervention - of which Fluconazole 150 mg is the first listed.
NCT05176379 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT05176379 about?
NCT05176379 is a clinical study titled "Endothelial Derived Hyperpolarization Factor and Vascular Control". Most cardiometabolic diseases are characterized by increased muscle sympathetic nerve activity (MSNA) during rest and exercise which contributes to poor health outcomes. In healthy humans during muscle contraction, there is a blunting of skeletal muscle vascular responsiveness to increases in MSNA. ...
What is the current status of trial NCT05176379?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 30 participants. The study started on 2022-02-19. Estimated completion is 2025-05.
What conditions does trial NCT05176379 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT05176379?
The interventions under investigation include: Fluconazole 150 mg (DRUG).
Who is sponsoring clinical trial NCT05176379?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05176379 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05176379's enrollment target sits among peer trials
30 678th of 1090 higher than 363 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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