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NCT05159518 · ClinicalTrials.gov registry record · Phase 1
A Study of PRT2527 in Participants With Advanced Solid Tumors
A Phase 1 study, sponsored by Prelude Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 30
- Enrollment target
NCT05159518: Completed Phase 1 study, sponsored by Prelude Therapeutics.
NCT05159518 is a Phase 1 study that has completed, run by Prelude Therapeutics. The registered enrollment target is 30 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (50% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05159518, a Phase 1 study, has completed, sponsored by Prelude Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 30 participants
- Enrollment target
Study Summary
This is a Phase 1 dose-escalation and confirmation study of PRT2527, a Cyclin-dependent Kinase 9 (CDK9) inhibitor, in participants with advanced solid tumors. The purpose of this study is to define the dosing schedule, and maximally tolerated dose to be used in subsequent development of PRT2527.
Primary Outcome
Dose limiting toxicities will be evaluated over the 21-day observation period
Interventions
- DRUG PRT2527
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2022-02-14 |
| Est. Completion | 2023-12-06 |
| Phase | Phase 1 |
What the finished NCT05159518 record still lists
NCT05159518 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (50% lower).
The record links to 0 conditions, and to 1 intervention - of which PRT2527 is the first listed.
NCT05159518 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05159518 about?
NCT05159518 is a clinical study titled "A Study of PRT2527 in Participants With Advanced Solid Tumors". This is a Phase 1 dose-escalation and confirmation study of PRT2527, a Cyclin-dependent Kinase 9 (CDK9) inhibitor, in participants with advanced solid tumors. The purpose of this study is to define the dosing schedule, and maximally tolerated dose to be used in subsequent development of PRT2527.
What is the current status of trial NCT05159518?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2022-02-14. Estimated completion is 2023-12-06.
What interventions are being tested in trial NCT05159518?
The interventions under investigation include: PRT2527 (DRUG).
Who is sponsoring clinical trial NCT05159518?
This trial is sponsored by Prelude Therapeutics, which has 12 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05159518's enrollment target sits among peer trials
30 1332nd of 2000 higher than 561 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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