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NCT05157945 · ClinicalTrials.gov registry record · Phase 2
ALTO-300 in Depression (ALTO-300-004)
A Phase 2 study of Major Depressive Disorder, sponsored by Alto Neuroscience.
- Completed
- Registry status
- Phase 2
- Development phase
- 148
- Enrollment target
- 4
- Study locations
NCT05157945: Completed Phase 2 study of Major Depressive Disorder, sponsored by Alto Neuroscience.
NCT05157945 is a Phase 2 study of Major Depressive Disorder that has completed, run by Alto Neuroscience. The registered enrollment target is 148 participants, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (61% lower). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05157945, a Phase 2 study of Major Depressive Disorder, has completed, sponsored by Alto Neuroscience.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 148 participants
- Enrollment target
- 4
- Study locations
Study Summary
The purpose of this study is to collect biologically-based data for defining predictors and correlates of the effects of ALTO-300.
Primary Outcome
The Montgomery-Åsberg Depression Rating Scale (MADRS) measures the severity of depression where smaller scores indicate less depression and higher scores suggest more severe depression. Possible scores for this 10 item version range from 0 to 60. The change from baseline to the end of the study is the primary outcome.
Conditions Studied
Interventions
- DRUG ALTO-300 PO Tablet
Study Locations (4)
Georgia
- Cerebral - Atlanta - Atlanta
Mississippi
- Site 171 - Jackson
New York
- Cerebral - New York City - New York
Texas
- Cerebral - Dallas - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 148 participants |
| Start Date | 2022-02-03 |
| Est. Completion | 2023-05-05 |
| Phase | Phase 2 |
What the finished NCT05157945 record still lists
NCT05157945 is an interventional study that assigns participants to a tested intervention. The registered 148 participants enrollment target is mid-sized for trials with a published cap, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (61% lower).
The record links to 1 condition, with Major Depressive Disorder appearing as the primary indexed condition, and to 1 intervention - of which ALTO-300 PO Tablet is the first listed.
NCT05157945 reports a single indexed study location in Georgia, Mississippi, New York.
Frequently Asked Questions
What is clinical trial NCT05157945 about?
NCT05157945 is a clinical study titled "ALTO-300 in Depression (ALTO-300-004)". The purpose of this study is to collect biologically-based data for defining predictors and correlates of the effects of ALTO-300.
What is the current status of trial NCT05157945?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 148 participants. The study started on 2022-02-03. Estimated completion is 2023-05-05.
What conditions does trial NCT05157945 study?
This clinical trial studies the following conditions: Major Depressive Disorder.
What interventions are being tested in trial NCT05157945?
The interventions under investigation include: ALTO-300 PO Tablet (DRUG).
Who is sponsoring clinical trial NCT05157945?
This trial is sponsored by Alto Neuroscience, which has 10 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05157945 being conducted?
This trial has 4 study locations across Georgia, Mississippi, New York, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05157945's enrollment target sits among peer trials
148 101st of 282 higher than 180 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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