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NCT05147558 · ClinicalTrials.gov registry record · Phase 2
A Study of Pembrolizumab With Lenvatinib in Women With Advanced Uterine Carcinosarcoma
A Phase 2 study of Uterine Carcinosarcoma and Advanced Uterine Carcinosarcoma, sponsored by Memorial Sloan Kettering Cancer Center.
- Active
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 7
- Study locations
NCT05147558: Active Phase 2 study of Uterine Carcinosarcoma and Advanced Uterine Carcinosarcoma, sponsored by Memorial Sloan Kettering Cancer Center.
NCT05147558 is a Phase 2 study of Uterine Carcinosarcoma and Advanced Uterine Carcinosarcoma that is active but no longer recruiting, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 40 participants, below the 145-participant average among 3 other Uterine Carcinosarcoma trials with a reported enrollment target (72% lower). The trial reports 7 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05147558, a Phase 2 study of Uterine Carcinosarcoma and Advanced Uterine Carcinosarcoma, is active but no longer recruiting, sponsored by Memorial Sloan Kettering Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 7
- Study locations
Study Summary
The purpose of this study to find out whether the combination of lenvatinib and pembrolizumab is an effective treatment for advanced uterine carcinosarcoma. The researchers will also do tests to find out whether biomarkers in the blood can predict the cancer's response to the study treatment. A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition
Primary Outcome
RECIST v 1.1 assessments
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Lenvatinib
Study Locations (7)
New York
- Memorial Sloan Kettering Suffolk- Commack (Limited Protocol Activities) - Commack
- Memorial Sloan Kettering Westchester (Limited protocol activities) - Harrison
- Memorial Sloan Kettering Cancer Center - New York
- Memorial Sloan Kettering Nassau (Limited protocol activities) - Rockville Centre
New Jersey
- Memorial Sloan Kettering Basking Ridge (Limited protocol activities) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Limited protocol activities) - Middletown
- Memorial Sloan Kettering Bergen (Limited protocol activities) - Montvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2021-12-23 |
| Est. Completion | 2026-12-23 |
| Phase | Phase 2 |
What the registry record for NCT05147558 still lists
NCT05147558 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 145-participant average among 3 other Uterine Carcinosarcoma trials with a reported enrollment target (72% lower).
The record links to 2 conditions, with Uterine Carcinosarcoma appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT05147558 lists 7 locations in 2 states (New York, New Jersey).
Frequently Asked Questions
What is clinical trial NCT05147558 about?
NCT05147558 is a clinical study titled "A Study of Pembrolizumab With Lenvatinib in Women With Advanced Uterine Carcinosarcoma". The purpose of this study to find out whether the combination of lenvatinib and pembrolizumab is an effective treatment for advanced uterine carcinosarcoma. The researchers will also do tests to find out whether biomarkers in the blood can predict the cancer's response to the study treatment. A biom...
What is the current status of trial NCT05147558?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2021-12-23. Estimated completion is 2026-12-23.
What conditions does trial NCT05147558 study?
This clinical trial studies the following conditions: Uterine Carcinosarcoma, Advanced Uterine Carcinosarcoma.
What interventions are being tested in trial NCT05147558?
The interventions under investigation include: Pembrolizumab (DRUG), Lenvatinib (DRUG).
Who is sponsoring clinical trial NCT05147558?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05147558 being conducted?
This trial has 7 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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