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NCT05138718 · ClinicalTrials.gov registry record
FDG an Myocardial Infarction: The PIAF Trial
A clinical trial of History of Myocardial Infarction, sponsored by International Atomic Energy Agency.
- Recruiting
- Registry status
- 2,041
- Enrollment target
- 1
- Study location
NCT05138718 is a study of History of Myocardial Infarction that is actively recruiting participants, run by International Atomic Energy Agency. The registered enrollment target is 2,041 participants. The trial reports 1 study location across 1 state.
The verdict
NCT05138718, a study of History of Myocardial Infarction, is actively recruiting participants, sponsored by International Atomic Energy Agency.
- RECRUITING
- Registry status
- 2,041 participants
- Enrollment target
- 1
- Study location
Study Summary
In order to define distinct and reliable arterial 18Fluorodeoxyglucose (FDG) thresholds identifying patients at risk for cardiovascular events, patients with a history of myocardial infarction will be included in this international multicenter trial. Non-enhanced whole-body FDG PET/CT will be performed in all patients and the arterial FDG uptake in the carotid arteries as well as the aorta will be quantified by calculating different uptake parameters. In addition, FDG uptake in hematopoietic tissues (spleen, bone marrow), visceral adipose tissue (VAT) and different brain regions (e. g. amygdala) will be measured. Furthermore, specific blood biomarkers including genetic biomarkers, which are linked to atherosclerotic disease with predictive power for future cardiovascular events, will be analyzed in a subgroup of patients. In part 2 of the trial, a 4-year follow-up period will be analyzed with a focus on the prediction of cardiovascular events (acute coronary syndrome, non-fatal ischemic stroke, ischemic cardiac death, other causes of death, coronary/vascular revascularization, new-onset of angina, symptomatic peripheral arterial disease and heart failure). The predictive value of the arterial, hematopoietic and cerebral FDG uptake parameters as well as of the specific blood and genetic biomarkers will be determined.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST 18F-FDG PET/CT
Study Locations (1)
Massachusetts
- Massachusetts General Hospital, Havard Medical School - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,041 participants |
| Start Date | 2021-12-01 |
| Est. Completion | 2026-07-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05138718
The ClinicalTrials.gov registry entry for NCT05138718 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 2,041 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is International Atomic Energy Agency, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with History of Myocardial Infarction appearing as the primary indexed condition, and to 1 intervention - of which 18F-FDG PET/CT is the first listed.
NCT05138718 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05138718 about?
NCT05138718 is a clinical study titled "FDG an Myocardial Infarction: The PIAF Trial". In order to define distinct and reliable arterial 18Fluorodeoxyglucose (FDG) thresholds identifying patients at risk for cardiovascular events, patients with a history of myocardial infarction will be included in this international multicenter trial. Non-enhanced whole-body FDG PET/CT will be perfor...
What is the current status of trial NCT05138718?
This trial is currently recruiting. The enrollment target is 2,041 participants. The study started on 2021-12-01. Estimated completion is 2026-07-01.
What conditions does trial NCT05138718 study?
This clinical trial studies the following conditions: History of Myocardial Infarction.
What interventions are being tested in trial NCT05138718?
The interventions under investigation include: 18F-FDG PET/CT (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05138718?
This trial is sponsored by International Atomic Energy Agency, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05138718 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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