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NCT05123859 · ClinicalTrials.gov registry record
Patterns of Natural Aging and the Role of Senescence Registry
A clinical trial, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- 250
- Enrollment target
NCT05123859: Completed study, sponsored by University of North Carolina, Chapel Hill.
NCT05123859 is a clinical trial that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 250 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05123859 has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- 250 participants
- Enrollment target
Study Summary
This is a registry to identify changes in the expression of aging-related biomarkers, changes in functional performance, and/or changes in quality-of-life across the aging spectrum in 250 participants ≥ 25 years of age that will be conducted by the University of North Carolina. The primary purpose of this registry is to measure biomarkers of aging/senescence and build computational models of aging in order to better understand the role of senescence in aging-related functional decline and differences between aging in a general population vs cohorts enriched for aging related disease (cancer, heart disease). Aging biomarker data in cohorts with cancer and heart disease has already been collected; the current study will enroll participants into the cohort of aging in the general population (Aging Cohort). Over the past century, life expectancy has increased by 30 years. With that gain has come a dramatic rise in age-related disease and an urgent need to understand, prevent, and treat these conditions. While age-related diseases have diverse phenotypes, there is increasing recognition of common biological underpinnings with cellular senescence as the nexus linking subcellular changes due to epigenetic changes, DNA damage, and mitochondria dysfunction with a decline in health due to multi-morbidity. The molecular changes that shift one's aging trajectory from a 'healthy' state to a 'disease' state are poorly understood; however, there is increasing evidence that senescence plays a key role in this shift. Computational models of natural aging and aging related disease are important tools in understanding the phenomenon of senescence, its regulation and dynamics, and its role in physiological or pathological processes during human aging. These findings will serve as pilot data for future analysis of cellular senescence, as measured by p16INK4 (hereafter referred to as p16) expression, and aging in other cohorts and begin to establish comparisons between p16 and other pot
Primary Outcome
The purpose of this registry is to collect aging biomarker data in a general population across the entire lifespan (Aging Cohort) to build several computational models of aging in order to better understand senescence in the context of general aging or specific aging associated diseases. Data collected following informed consent. Participants provide 1 time only blood sample and answer questionnaires; no follow up.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2022-01-05 |
| Est. Completion | 2022-08-14 |
What the finished NCT05123859 record still lists
NCT05123859 is an observational study that tracks outcomes without assigning an intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT05123859 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05123859 about?
NCT05123859 is a clinical study titled "Patterns of Natural Aging and the Role of Senescence Registry". This is a registry to identify changes in the expression of aging-related biomarkers, changes in functional performance, and/or changes in quality-of-life across the aging spectrum in 250 participants ≥ 25 years of age that will be conducted by the University of North Carolina. The primary purpose o...
What is the current status of trial NCT05123859?
This trial is currently completed. The enrollment target is 250 participants. The study started on 2022-01-05. Estimated completion is 2022-08-14.
Who is sponsoring clinical trial NCT05123859?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
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