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NCT05119335 · ClinicalTrials.gov registry record · Phase 1
A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma
A Phase 1 study, sponsored by NiKang Therapeutics.
- Terminated
- Registry status
- Phase 1
- Development phase
- 120
- Enrollment target
NCT05119335: Clinical Trial Phase 1 study, sponsored by NiKang Therapeutics.
NCT05119335 is a Phase 1 study that was terminated before completion, run by NiKang Therapeutics. The registered enrollment target is 120 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (100% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05119335, a Phase 1 study, was terminated before completion, sponsored by NiKang Therapeutics.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 120 participants
- Enrollment target
Study Summary
The goal of the Phase 1 portion is to identify the maximum tolerated dose (MTD) and/or the recommended doses for expansion (RDEs) of NKT2152. The Phase 2 portion will evaluate the efficacy of NKT2152 in ccRCC.
Primary Outcome
DLTs graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5 .0.
Interventions
- DRUG Oral NKT2152
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2021-10-26 |
| Est. Completion | 2025-09-30 |
| Phase | Phase 1 |
Why NCT05119335 stopped before completion
NCT05119335 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (100% higher).
The record links to 0 conditions, and to 1 intervention - of which Oral NKT2152 is the first listed.
NCT05119335 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05119335 about?
NCT05119335 is a clinical study titled "A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma". The goal of the Phase 1 portion is to identify the maximum tolerated dose (MTD) and/or the recommended doses for expansion (RDEs) of NKT2152. The Phase 2 portion will evaluate the efficacy of NKT2152 in ccRCC.
What is the current status of trial NCT05119335?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 120 participants. The study started on 2021-10-26. Estimated completion is 2025-09-30.
What interventions are being tested in trial NCT05119335?
The interventions under investigation include: Oral NKT2152 (DRUG).
Who is sponsoring clinical trial NCT05119335?
This trial is sponsored by NiKang Therapeutics, which has 5 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05119335's enrollment target sits among peer trials
120 479th of 2000 higher than 1,503 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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