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NCT05103176 · ClinicalTrials.gov registry record · NA
Brain State-dependent Stimulation to Improve Movement
A NA study, sponsored by University of Michigan.
- Completed
- Registry status
- NA
- Development phase
- 59
- Enrollment target
NCT05103176: Completed NA study, sponsored by University of Michigan.
NCT05103176 is a NA study that has completed, run by University of Michigan. The registered enrollment target is 59 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05103176, a NA study, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- NA
- Development phase
- 59 participants
- Enrollment target
Study Summary
Repetitive transcranial magnetic stimulation (rTMS) is a powerful tool to non-invasively modulate brain circuits, brain plasticity, and behavior. This proposal will test the hypothesis that controlling behavioral state during focal multi-day rTMS of a brain region involved in grasping movements will enhance the functional specificity of the neuromodulation action among distributed brain regions involved in voluntary motor control and concomitantly improve manual dexterity. Results from this study will be used to optimize rTMS therapy for individuals with neuromotor impairments by controlling behavioral state to improve the efficacy of rTMS treatment. Healthy volunteers that qualify for this study will have motor skill assessments and basic neuromotor testing (using neurophysiology with TMS and functional Magnetic Resonance Imaging (fMRI) scans). Participants will be asked to come in for up to nine sessions that include 1 screening session, 5 consecutive daily rTMS sessions and 3 assessment sessions with resting-state and task-based fMRI, neurophysiology with TMS, and hand motor tasks over the course of 3-4 weeks.
Primary Outcome
9-hole peg test (9-HPT) is a manual dexterity measure in which a participant must place 9 pegs in board with 9 holes, and remove all 9 pegs upon the insertion of all 9 pegs. This is completed with one peg at a time, and only one hand is used. For our study, only the right hand was used. The performance is estimated as the time required to complete the task (seconds). A lower time in seconds is indicative of a better score. For percent change in performance, a higher positive percent is indicativ
Interventions
- DEVICE TMS
- BEHAVIORAL Object directed grasping
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 59 participants |
| Start Date | 2022-02-15 |
| Est. Completion | 2023-05-31 |
| Phase | NA |
What the finished NCT05103176 record still lists
NCT05103176 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 59 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which TMS is the first listed.
NCT05103176 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05103176 about?
NCT05103176 is a clinical study titled "Brain State-dependent Stimulation to Improve Movement". Repetitive transcranial magnetic stimulation (rTMS) is a powerful tool to non-invasively modulate brain circuits, brain plasticity, and behavior. This proposal will test the hypothesis that controlling behavioral state during focal multi-day rTMS of a brain region involved in grasping movements will...
What is the current status of trial NCT05103176?
This trial is currently completed. It is a NA study. The enrollment target is 59 participants. The study started on 2022-02-15. Estimated completion is 2023-05-31.
What interventions are being tested in trial NCT05103176?
The interventions under investigation include: TMS (DEVICE), Object directed grasping (BEHAVIORAL).
Who is sponsoring clinical trial NCT05103176?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05103176's enrollment target sits among peer trials
59 1256th of 2000 higher than 745 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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