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NCT05049863 · ClinicalTrials.gov registry record · Phase 1
Chemotherapy in Patients With Relapsed Small Cell Lung Cancer in Combination With Allopurinol and MycoPhenolate (CLAMP Trial)
A Phase 1 study, sponsored by Washington University School of Medicine.
- Terminated
- Registry status
- Phase 1
- Development phase
- 17
- Enrollment target
NCT05049863: Clinical Trial Phase 1 study, sponsored by Washington University School of Medicine.
NCT05049863 is a Phase 1 study that was terminated before completion, run by Washington University School of Medicine. The registered enrollment target is 17 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (72% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05049863, a Phase 1 study, was terminated before completion, sponsored by Washington University School of Medicine.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 17 participants
- Enrollment target
Study Summary
The hypothesis is that the addition of mycophenolate mofetil (MMF) and allopurinol to chemotherapy in patients with relapsed small cell lung cancer (SCLC) will be safely tolerated and improve outcomes, as measured by response rate and progression-free survival in patients compared to other single agent chemotherapy drugs used in historical controls.
Interventions
- DRUG Irinotecan
- DRUG Mycophenolate Mofetil
- DRUG Allopurinol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2023-02-27 |
| Est. Completion | 2024-11-17 |
| Phase | Phase 1 |
Why NCT05049863 stopped before completion
NCT05049863 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (72% lower).
The record links to 0 conditions, and to 3 interventions - of which Irinotecan is the first listed.
NCT05049863 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05049863 about?
NCT05049863 is a clinical study titled "Chemotherapy in Patients With Relapsed Small Cell Lung Cancer in Combination With Allopurinol and MycoPhenolate (CLAMP Trial)". The hypothesis is that the addition of mycophenolate mofetil (MMF) and allopurinol to chemotherapy in patients with relapsed small cell lung cancer (SCLC) will be safely tolerated and improve outcomes, as measured by response rate and progression-free survival in patients compared to other single ag...
What is the current status of trial NCT05049863?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 17 participants. The study started on 2023-02-27. Estimated completion is 2024-11-17.
What interventions are being tested in trial NCT05049863?
The interventions under investigation include: Irinotecan (DRUG), Mycophenolate Mofetil (DRUG), Allopurinol (DRUG).
Who is sponsoring clinical trial NCT05049863?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05049863's enrollment target sits among peer trials
17 1785th of 2000 higher than 215 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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