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NCT05048485 · ClinicalTrials.gov registry record
Tuberculosis - Learning the Effect of Parasites and Reinforcing Diets
A clinical trial of Malnutrition and Tuberculosis, Pulmonary, sponsored by Boston Medical Center.
- Completed
- Registry status
- 141
- Enrollment target
- 2
- Study locations
NCT05048485: Completed study of Malnutrition and Tuberculosis, Pulmonary, sponsored by Boston Medical Center.
NCT05048485 is a study of Malnutrition and Tuberculosis, Pulmonary that has completed, run by Boston Medical Center. The registered enrollment target is 141 participants, below the 380-participant average among 17 other Malnutrition trials with a reported enrollment target (63% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05048485, a study of Malnutrition and Tuberculosis, Pulmonary, has completed, sponsored by Boston Medical Center.
- COMPLETED
- Registry status
- 141 participants
- Enrollment target
- 2
- Study locations
Study Summary
The objectives of this research are to determine: * the burden of intestinal parasitic infections among persons living with pulmonary tuberculosis (TB) * whether intestinal parasitic infections alter TB treatment outcomes, including speed of sputum clearance and treatment outcomes * the impact of malnutrition on speed of sputum clearance and TB treatment outcomes * whether nutritional supplementation improves speed of sputum clearance and treatment outcomes In this study the researchers will investigate how intestinal parasites impact the nutritional status of TB patients before the start of nutritional supplementation and how they alter the trajectory of weight gain in those receiving supplementation by analyzing results from 2 cohorts. LEOPARD Cohort 1- * Control-Enroll TB cases, screen for undernutrition, obtain stool for intestinal parasite screening by polymerase chain reaction (PCR), and assess them for treatment outcomes and weight gain * TB LION (Learning Impact of Nutrition) - Enroll TB cases, provide nutritional supplementation for 6 months (as part of existing TB LION study), screen for undernutrition, obtain stool for intestinal parasite screening by PCR, and assess them for treatment outcomes and weight gain LEOPARD Cohort 2 - * Enroll TB cases, screen for undernutrition, obtain stool for internal parasite screening by PCR, and assess them for treatment outcomes and weight gain.
Primary Outcome
The number of participants that successfully completed treatment without bacteriological evidence of failure for two continuous weeks will be divided by the number of participants who started TB treatment.
Conditions Studied
Study Locations (2)
Massachusetts
- Boston Medical Center - Boston
Other
- Jawaharlal Institute of Postgraduate Medical Education and Research - Puducherry
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 141 participants |
| Start Date | 2022-04-09 |
| Est. Completion | 2025-07-21 |
What the finished NCT05048485 record still lists
NCT05048485 is an observational study that tracks outcomes without assigning an intervention. The registered 141 participants enrollment target is mid-sized for trials with a published cap, below the 380-participant average among 17 other Malnutrition trials with a reported enrollment target (63% lower).
The record links to 3 conditions, with Malnutrition appearing as the primary indexed condition, and to 0 interventions.
NCT05048485 reports a single indexed study location in Massachusetts, Other.
Frequently Asked Questions
What is clinical trial NCT05048485 about?
NCT05048485 is a clinical study titled "Tuberculosis - Learning the Effect of Parasites and Reinforcing Diets". The objectives of this research are to determine: * the burden of intestinal parasitic infections among persons living with pulmonary tuberculosis (TB) * whether intestinal parasitic infections alter TB treatment outcomes, including speed of sputum clearance and treatment outcomes * the impact of m...
What is the current status of trial NCT05048485?
This trial is currently completed. The enrollment target is 141 participants. The study started on 2022-04-09. Estimated completion is 2025-07-21.
What conditions does trial NCT05048485 study?
This clinical trial studies the following conditions: Malnutrition, Tuberculosis, Pulmonary, Helminthiasis.
Who is sponsoring clinical trial NCT05048485?
This trial is sponsored by Boston Medical Center, which has 253 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05048485 being conducted?
This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05048485's enrollment target sits among peer trials
141 10th of 17 higher than 8 of 17 other Malnutrition trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Malnutrition trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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