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NCT05046184 · ClinicalTrials.gov registry record · Phase 2
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets
A Phase 2 study, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- Phase 2
- Development phase
- 165
- Enrollment target
NCT05046184: Completed Phase 2 study, sponsored by University of Texas Southwestern Medical Center.
NCT05046184 is a Phase 2 study that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 165 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (24% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05046184, a Phase 2 study, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 165 participants
- Enrollment target
Study Summary
The study is investigating dysfunctions in neurocircuitry in regards to irritability with healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing MRIs. The MDD group will also be randomized to receive ketamine or midazolam to investigate changes post-treatment in neurocircuitry with regards to irritability.
Primary Outcome
Resting-state functional connectivity between striatum and habenula will be measured by functional magnetic resonance imaging (fMRI) in healthy controls and in adults with major depressive disorder (MDD). Functional connectivity refers to the standardized correlation between resting state BOLD signal of the striatum and habenula regions of the brain.
Interventions
- DRUG Ketamine Hydrochloride
- DRUG Midazolam injection
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 165 participants |
| Start Date | 2022-05-05 |
| Est. Completion | 2025-04-30 |
| Phase | Phase 2 |
What the finished NCT05046184 record still lists
NCT05046184 is an interventional study that assigns participants to a tested intervention. The registered 165 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (24% higher).
The record links to 0 conditions, and to 2 interventions - of which Ketamine Hydrochloride is the first listed.
NCT05046184 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05046184 about?
NCT05046184 is a clinical study titled "Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets". The study is investigating dysfunctions in neurocircuitry in regards to irritability with healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing MRIs. The MDD group will also be randomized to receive ketamine or midazolam to investigate changes post-treatment in neu...
What is the current status of trial NCT05046184?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 165 participants. The study started on 2022-05-05. Estimated completion is 2025-04-30.
What interventions are being tested in trial NCT05046184?
The interventions under investigation include: Ketamine Hydrochloride (DRUG), Midazolam injection (DRUG).
Who is sponsoring clinical trial NCT05046184?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05046184's enrollment target sits among peer trials
165 410th of 2000 higher than 1,588 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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