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A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies
NCT05039177 · View on ClinicalTrials.gov ↗
Study Summary
* To evaluate the safety and tolerability of escalating doses of ERAS-007 in combination with other cancer therapies in study participants with advanced GI malignancies. * To determine the Maximum Tolerated Dose (MTD) and/or Recommended Dose (RD) of ERAS-007 administered in combination with other cancer therapies. * To evaluate the antitumor activity of ERAS-007 in combination with other cancer therapies. * To evaluate the PK profiles of ERAS-007 and other cancer therapies when administered in combination.
Conditions Studied
Interventions
- DRUG Cetuximab
- DRUG Palbociclib
- DRUG Encorafenib
- DRUG ERAS-007
Study Locations (14)
California
- City of Hope — Duarte
- University of California Irvine College of Medicine — Orange
- UCSF Mount Zion Medical Ctr — San Francisco
Alabama
- University of Alabama at Birmingham (O'Neal Comprehensive Cancer Center) — Birmingham
Maryland
- The Johns Hopkins Hospital — Baltimore
Massachusetts
- Massachusetts General Hospital — Boston
Michigan
- Henry Ford Cancer Institute — Detroit
Missouri
- Washington University (Siteman Cancer Center) — St Louis
North Carolina
- Duke Cancer Institute — Durham
Oklahoma
- Stephenson Cancer Center — Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 102 participants |
| Start Date | 2021-09-20 |
| Est. Completion | 2025-12 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05039177
The ClinicalTrials.gov registry entry for NCT05039177 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 102 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Erasca, which has 7 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Metastatic Colorectal Cancer appearing as the primary indexed condition, and to 4 interventions — of which Cetuximab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05039177 reports 14 study locations spanning 12 distinct geographic areas — top geographies include California, Alabama, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05039177 about?
NCT05039177 is a clinical study titled "A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies". * To evaluate the safety and tolerability of escalating doses of ERAS-007 in combination with other cancer therapies in study participants with advanced GI malignancies. * To determine the Maximum Tolerated Dose (MTD) and/or Recommended Dose (RD) of ERAS-007 administered in combination with other ca...
What is the current status of trial NCT05039177?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 102 participants. The study started on 2021-09-20. Estimated completion is 2025-12.
What conditions does trial NCT05039177 study?
This clinical trial studies the following conditions: Metastatic Colorectal Cancer, Metastatic Pancreatic Ductal Adenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05039177?
The interventions under investigation include: Cetuximab (DRUG), Palbociclib (DRUG), Encorafenib (DRUG), ERAS-007 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05039177?
This trial is sponsored by Erasca, which has 7 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05039177 being conducted?
This trial has 14 study locations across Alabama, California, Maryland, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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