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NCT05011422 · ClinicalTrials.gov registry record · Phase 1
Haploidentical Hematopoietic Stem Cell Transplantation With Ex Vivo TCR Alpha/Beta and CD19 Depletion in Pediatric Hematologic Malignancies
A Phase 1 study of Pediatric Hematologic Malignancies, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT05011422 is a Phase 1 study of Pediatric Hematologic Malignancies that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 50 participants. The trial reports 1 study location across 1 state.
The verdict
NCT05011422, a Phase 1 study of Pediatric Hematologic Malignancies, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
This single arm pilot phase I study with safety run-in is designed to estimate the safety and efficacy of a familial mismatched or haploidentical hematopoietic stem cell transplantation (haplo-HSCT) using a novel graft modification technique (selective αβ-TCR and CD19 depletion).
Conditions Studied
Interventions
- DEVICE Ex Vivo T-cell receptor alpha-beta and CD19+ Depletion using CliniMACs Plus
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2022-11-03 |
| Est. Completion | 2029-05-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05011422
The ClinicalTrials.gov registry entry for NCT05011422 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Pediatric Hematologic Malignancies appearing as the primary indexed condition, and to 1 intervention - of which Ex Vivo T-cell receptor alpha-beta and CD19+ Depletion using CliniMACs Plus is the first listed.
NCT05011422 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT05011422 about?
NCT05011422 is a clinical study titled "Haploidentical Hematopoietic Stem Cell Transplantation With Ex Vivo TCR Alpha/Beta and CD19 Depletion in Pediatric Hematologic Malignancies". This single arm pilot phase I study with safety run-in is designed to estimate the safety and efficacy of a familial mismatched or haploidentical hematopoietic stem cell transplantation (haplo-HSCT) using a novel graft modification technique (selective αβ-TCR and CD19 depletion).
What is the current status of trial NCT05011422?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2022-11-03. Estimated completion is 2029-05-31.
What conditions does trial NCT05011422 study?
This clinical trial studies the following conditions: Pediatric Hematologic Malignancies.
What interventions are being tested in trial NCT05011422?
The interventions under investigation include: Ex Vivo T-cell receptor alpha-beta and CD19+ Depletion using CliniMACs Plus (DEVICE).
Who is sponsoring clinical trial NCT05011422?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05011422 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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