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NCT04986683 · ClinicalTrials.gov registry record · NA
Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery
A NA study of Focal Epilepsy, sponsored by Wayne State University.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT04986683: Recruiting NA study of Focal Epilepsy, sponsored by Wayne State University.
NCT04986683 is a NA study of Focal Epilepsy that is actively recruiting participants, run by Wayne State University. The registered enrollment target is 60 participants, below the 165-participant average among 8 other Focal Epilepsy trials with a reported enrollment target (64% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04986683, a NA study of Focal Epilepsy, is actively recruiting participants, sponsored by Wayne State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
This project will test the accuracy of a novel diffusion-weighted magnetic resonance imaging (DWMRI) approach using a deep convolutional neural network (DCNN) to predict an optimal resection margin for pediatric epilepsy surgery objectively. Its primary goal is to minimize surgical risk probability (i.e., functional deficit) and maximize surgical benefit probability (i.e., seizure freedom) by precisely localizing eloquent white matter pathways in children and adolescents with drug-resistant focal epilepsy. This new imaging approach, which will acquire a DWMRI scan before pediatric epilepsy surgery in about 10 minutes without contrast administration (and also without sedation even in young children), can be readily applied to improve preoperative benefit-risk evaluation for pediatric epilepsy surgery in the future. The investigators will also study how the advanced DWMRI-DCNN connectome approach can detect complex signs of brain neuronal reorganization that help improve neurological and cognitive outcomes following pediatric epilepsy surgery. This new imaging approach could benefit targeted interventions in the future to minimize neurocognitive deficits in affected children. All enrolled subjects will undergo advanced brain MRI and neurocognitive evaluation to achieve these goals. The findings of this project will not guide any clinical decision-making or clinical intervention until the studied approach is thoroughly validated.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Brain magnetic resonance imaging
- BEHAVIORAL Neuro-psychology testing
Study Locations (1)
Michigan
- Wayne State University/Children's Hospital of Michigan - Detroit
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2021-08-01 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT04986683 shows while recruiting
NCT04986683 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 165-participant average among 8 other Focal Epilepsy trials with a reported enrollment target (64% lower).
The record links to 1 condition, with Focal Epilepsy appearing as the primary indexed condition, and to 2 interventions - of which Brain magnetic resonance imaging is the first listed.
NCT04986683 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT04986683 about?
NCT04986683 is a clinical study titled "Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery". This project will test the accuracy of a novel diffusion-weighted magnetic resonance imaging (DWMRI) approach using a deep convolutional neural network (DCNN) to predict an optimal resection margin for pediatric epilepsy surgery objectively. Its primary goal is to minimize surgical risk probability ...
What is the current status of trial NCT04986683?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2021-08-01. Estimated completion is 2026-06-30.
What conditions does trial NCT04986683 study?
This clinical trial studies the following conditions: Focal Epilepsy.
What interventions are being tested in trial NCT04986683?
The interventions under investigation include: Brain magnetic resonance imaging (DIAGNOSTIC_TEST), Neuro-psychology testing (BEHAVIORAL).
Who is sponsoring clinical trial NCT04986683?
This trial is sponsored by Wayne State University, which has 163 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04986683 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Focal Epilepsy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04986683's enrollment target sits among peer trials
60 5th of 8 higher than 4 of 8 other Focal Epilepsy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Focal Epilepsy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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