Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04986683 · ClinicalTrials.gov registry record · NA
Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery
A NA study of Focal Epilepsy, sponsored by Wayne State University.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT04986683 is a NA study of Focal Epilepsy that is actively recruiting participants, run by Wayne State University. The registered enrollment target is 60 participants, below the 165-participant average among 8 other Focal Epilepsy trials with a reported enrollment target (64% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04986683, a NA study of Focal Epilepsy, is actively recruiting participants, sponsored by Wayne State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
This project will test the accuracy of a novel diffusion-weighted magnetic resonance imaging (DWMRI) approach using a deep convolutional neural network (DCNN) to predict an optimal resection margin for pediatric epilepsy surgery objectively. Its primary goal is to minimize surgical risk probability (i.e., functional deficit) and maximize surgical benefit probability (i.e., seizure freedom) by precisely localizing eloquent white matter pathways in children and adolescents with drug-resistant focal epilepsy. This new imaging approach, which will acquire a DWMRI scan before pediatric epilepsy surgery in about 10 minutes without contrast administration (and also without sedation even in young children), can be readily applied to improve preoperative benefit-risk evaluation for pediatric epilepsy surgery in the future. The investigators will also study how the advanced DWMRI-DCNN connectome approach can detect complex signs of brain neuronal reorganization that help improve neurological and cognitive outcomes following pediatric epilepsy surgery. This new imaging approach could benefit targeted interventions in the future to minimize neurocognitive deficits in affected children. All enrolled subjects will undergo advanced brain MRI and neurocognitive evaluation to achieve these goals. The findings of this project will not guide any clinical decision-making or clinical intervention until the studied approach is thoroughly validated.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Brain magnetic resonance imaging
- BEHAVIORAL Neuro-psychology testing
Study Locations (1)
Michigan
- Wayne State University/Children's Hospital of Michigan - Detroit
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2021-08-01 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04986683
The ClinicalTrials.gov registry entry for NCT04986683 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 165-participant average among 8 other Focal Epilepsy trials with a reported enrollment target (64% lower). The listed sponsor is Wayne State University, which has 163 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Focal Epilepsy appearing as the primary indexed condition, and to 2 interventions - of which Brain magnetic resonance imaging is the first listed.
NCT04986683 reports 1 study location spanning 1 distinct geographic area - top geographies include Michigan.
Frequently Asked Questions
What is clinical trial NCT04986683 about?
NCT04986683 is a clinical study titled "Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery". This project will test the accuracy of a novel diffusion-weighted magnetic resonance imaging (DWMRI) approach using a deep convolutional neural network (DCNN) to predict an optimal resection margin for pediatric epilepsy surgery objectively. Its primary goal is to minimize surgical risk probability ...
What is the current status of trial NCT04986683?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2021-08-01. Estimated completion is 2026-06-30.
What conditions does trial NCT04986683 study?
This clinical trial studies the following conditions: Focal Epilepsy.
What interventions are being tested in trial NCT04986683?
The interventions under investigation include: Brain magnetic resonance imaging (DIAGNOSTIC_TEST), Neuro-psychology testing (BEHAVIORAL).
Who is sponsoring clinical trial NCT04986683?
This trial is sponsored by Wayne State University, which has 163 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04986683 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Focal Epilepsy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Breathing Rescue for SUDEP Prevention
RECRUITING · NA
-
Study of Transcranial Direct Current Stimulation to Treat Epilepsy
RECRUITING · NA
-
Sleep Architecture & Cognition in Focal Epilepsy
RECRUITING · NA
-
Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
RECRUITING · NA
-
Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
RECRUITING · Phase 2
-
A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures
RECRUITING · Phase 2
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.