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NCT04977765 · ClinicalTrials.gov registry record
Cardiometabolic Health in Transgender Males
A clinical trial of Transgenderism and Transgender, sponsored by Medical College of Wisconsin.
- Active
- Registry status
- 90
- Enrollment target
- 1
- Study location
NCT04977765 is a study of Transgenderism and Transgender that is active but no longer recruiting, run by Medical College of Wisconsin. The registered enrollment target is 90 participants, above the 52-participant average among 5 other Transgenderism trials with a reported enrollment target (73% higher). The trial reports 1 study location across 1 state.
The verdict
NCT04977765, a study of Transgenderism and Transgender, is active but no longer recruiting, sponsored by Medical College of Wisconsin.
- ACTIVE NOT RECRUITING
- Registry status
- 90 participants
- Enrollment target
- 1
- Study location
Study Summary
Transgender individuals are those with a gender identity opposite the sex they were assigned at birth. Approximately 1% of the population is transgender, equating to \~60,000 transgender Wisconsinites. A transgender boy or man is someone with a 46,XX karyotype and typical female genitalia but a male gender identity and desire for more male-typical gender expression. Gender-affirming testosterone (hormonal) treatment (GAHT) is the cornerstone of masculinizing therapy for transgender men and boys, resulting in estrogen (E2) suppression and circulating testosterone (T) levels equivalent to cisgender males. Historically, GAHT was initiated after an E2-driven puberty, but the last decade has seen an explosion of referrals for GAHT in transboys, many of whom are exposed to only low E2 levels before puberty is halted with blocker therapy. Knowledge of risks incurred by GAHT rely on low-quality studies, precluding conclusive assessment of GAHT's long-term impact on cardiometabolic outcomes. Data on transboys receiving GAHT before completion of E2-driven puberty are sparser and no studies have addressed mechanisms by which GAHT may affect vascular physiology. The investigators aim to determine the cardiometabolic impact of GAHT in transboys/men and to determine if any differences identified are mechanistically dependent on the timing of GAHT relative to puberty.
Conditions Studied
Study Locations (1)
Wisconsin
- Medical College of Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2021-09-30 |
| Est. Completion | 2027-08-01 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04977765
The ClinicalTrials.gov registry entry for NCT04977765 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 52-participant average among 5 other Transgenderism trials with a reported enrollment target (73% higher). The listed sponsor is Medical College of Wisconsin, which has 447 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Transgenderism appearing as the primary indexed condition, and to 0 interventions.
NCT04977765 reports 1 study location spanning 1 distinct geographic area - top geographies include Wisconsin.
Frequently Asked Questions
What is clinical trial NCT04977765 about?
NCT04977765 is a clinical study titled "Cardiometabolic Health in Transgender Males". Transgender individuals are those with a gender identity opposite the sex they were assigned at birth. Approximately 1% of the population is transgender, equating to \~60,000 transgender Wisconsinites. A transgender boy or man is someone with a 46,XX karyotype and typical female genitalia but a male...
What is the current status of trial NCT04977765?
This trial is currently active not recruiting. The enrollment target is 90 participants. The study started on 2021-09-30. Estimated completion is 2027-08-01.
What conditions does trial NCT04977765 study?
This clinical trial studies the following conditions: Transgenderism, Transgender.
Who is sponsoring clinical trial NCT04977765?
This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04977765 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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