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NCT04946552 · ClinicalTrials.gov registry record · NA
Sympathetic Activation in Obesity
A NA study, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 5
- Enrollment target
NCT04946552 is a NA study that has completed, run by Yale University. The registered enrollment target is 5 participants.
The verdict
NCT04946552, a NA study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
Study Summary
The primary objective of this study is to determine whether sympathetic nervous system (SNS) activity in white adipose tissue (WAT) and brown adipose tissue (BAT), skeletal muscle and brain is altered in individuals with obesity in comparison to individuals with normal weight. Simultaneous multi-organ SNS activation will be obtained with a radiotracer for norepinephrine transporter (NET) for whole-body Positron Emission Tomography (PET) imaging and microneurography (peroneal muscle SNS activity). The secondary objectives of this study are: 1) to evaluate whether gender differences affect peripheral SNS in healthy normal weight and obese men and women in adipose tissue (WAT and BAT) and muscle (resting/fasting); 2) To investigate the relationship between peripheral and central SNS activity in obesity, by correlating SNS activity in peripheral tissues (WAT, BAT, and muscle) and brain; and 3) To investigate NET CNS and peripheral SNS activity before and after a high carbohydrate mixed meal in lean and obese men and women.
Interventions
- DIAGNOSTIC_TEST Oral Glucose Tolerance Test
- DIAGNOSTIC_TEST PET Scan
- DIETARY_SUPPLEMENT Mixed Meal Test
- DIAGNOSTIC_TEST Muscle sympathetic nerve activity (MSNA)
- OTHER Body Composition, Percent Body Fat & Percent Body Water (Tanita scale)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2021-11-23 |
| Est. Completion | 2022-09-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04946552
The ClinicalTrials.gov registry entry for NCT04946552 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 5 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Oral Glucose Tolerance Test is the first listed.
NCT04946552 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04946552 about?
NCT04946552 is a clinical study titled "Sympathetic Activation in Obesity". The primary objective of this study is to determine whether sympathetic nervous system (SNS) activity in white adipose tissue (WAT) and brown adipose tissue (BAT), skeletal muscle and brain is altered in individuals with obesity in comparison to individuals with normal weight. Simultaneous multi-org...
What is the current status of trial NCT04946552?
This trial is currently completed. It is a NA study. The enrollment target is 5 participants. The study started on 2021-11-23. Estimated completion is 2022-09-30.
What interventions are being tested in trial NCT04946552?
The interventions under investigation include: Oral Glucose Tolerance Test (DIAGNOSTIC_TEST), PET Scan (DIAGNOSTIC_TEST), Mixed Meal Test (DIETARY_SUPPLEMENT), Muscle sympathetic nerve activity (MSNA) (DIAGNOSTIC_TEST), Body Composition, Percent Body Fat & Percent Body Water (Tanita scale) (OTHER).
Who is sponsoring clinical trial NCT04946552?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
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