Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04946552 · ClinicalTrials.gov registry record · NA
Sympathetic Activation in Obesity
A NA study, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 5
- Enrollment target
NCT04946552: Completed NA study, sponsored by Yale University.
NCT04946552 is a NA study that has completed, run by Yale University. The registered enrollment target is 5 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04946552, a NA study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
Study Summary
The primary objective of this study is to determine whether sympathetic nervous system (SNS) activity in white adipose tissue (WAT) and brown adipose tissue (BAT), skeletal muscle and brain is altered in individuals with obesity in comparison to individuals with normal weight. Simultaneous multi-organ SNS activation will be obtained with a radiotracer for norepinephrine transporter (NET) for whole-body Positron Emission Tomography (PET) imaging and microneurography (peroneal muscle SNS activity). The secondary objectives of this study are: 1) to evaluate whether gender differences affect peripheral SNS in healthy normal weight and obese men and women in adipose tissue (WAT and BAT) and muscle (resting/fasting); 2) To investigate the relationship between peripheral and central SNS activity in obesity, by correlating SNS activity in peripheral tissues (WAT, BAT, and muscle) and brain; and 3) To investigate NET CNS and peripheral SNS activity before and after a high carbohydrate mixed meal in lean and obese men and women.
Primary Outcome
Lean individuals with a BMI of 18-25 and obese individuals with a BMI of 30-40 will undergo a PET/CT scan to determine group differences in sympathetic nervous system (SNS) activity in white adipose tissue (WAT), brown adipose tissue (BAT), and deltoid muscle. SNS activity will be determined by using \[11C\]MRB a radiotracer for PET imaging.
Interventions
- DIAGNOSTIC_TEST Oral Glucose Tolerance Test
- DIAGNOSTIC_TEST PET Scan
- DIETARY_SUPPLEMENT Mixed Meal Test
- DIAGNOSTIC_TEST Muscle sympathetic nerve activity (MSNA)
- OTHER Body Composition, Percent Body Fat & Percent Body Water (Tanita scale)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2021-11-23 |
| Est. Completion | 2022-09-30 |
| Phase | NA |
What the finished NCT04946552 record still lists
NCT04946552 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 5 interventions - of which Oral Glucose Tolerance Test is the first listed.
NCT04946552 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04946552 about?
NCT04946552 is a clinical study titled "Sympathetic Activation in Obesity". The primary objective of this study is to determine whether sympathetic nervous system (SNS) activity in white adipose tissue (WAT) and brown adipose tissue (BAT), skeletal muscle and brain is altered in individuals with obesity in comparison to individuals with normal weight. Simultaneous multi-org...
What is the current status of trial NCT04946552?
This trial is currently completed. It is a NA study. The enrollment target is 5 participants. The study started on 2021-11-23. Estimated completion is 2022-09-30.
What interventions are being tested in trial NCT04946552?
The interventions under investigation include: Oral Glucose Tolerance Test (DIAGNOSTIC_TEST), PET Scan (DIAGNOSTIC_TEST), Mixed Meal Test (DIETARY_SUPPLEMENT), Muscle sympathetic nerve activity (MSNA) (DIAGNOSTIC_TEST), Body Composition, Percent Body Fat & Percent Body Water (Tanita scale) (OTHER).
Who is sponsoring clinical trial NCT04946552?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04946552's enrollment target sits among peer trials
5 1988th of 2000 higher than 5 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI