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NCT04934956 · ClinicalTrials.gov registry record · NA
Increasing Gait Automaticity in Older Adults by Exploiting Locomotor Adaptation
A NA study of Community Mobility of Older Adults and Locomotor Adaptability, sponsored by University of Pittsburgh.
- Recruiting
- Registry status
- NA
- Development phase
- 42
- Enrollment target
- 1
- Study location
NCT04934956 is a NA study of Community Mobility of Older Adults and Locomotor Adaptability that is actively recruiting participants, run by University of Pittsburgh. The registered enrollment target is 42 participants. The trial reports 1 study location across 1 state.
The verdict
NCT04934956, a NA study of Community Mobility of Older Adults and Locomotor Adaptability, is actively recruiting participants, sponsored by University of Pittsburgh.
- RECRUITING
- Registry status
- NA
- Development phase
- 42 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators will test the following: 1) the extent of locomotor adaptation improvement in individuals aged 65 years and older; 2) the association between initial walking automaticity (i.e. less PFC activity while walking with a cognitive load) and prefrontal-subcortical function (measured via neuropsychological testing); and 3) whether improvements in locomotor adaptability result in improvements in the Functional Gait Assessment (FGA), a clinically relevant indicator of dynamic balance and mobility in older adults. To answer these questions, the investigators will combine innovative techniques from multiple laboratories at the University of Pittsburgh. Automatic motor control (Dr. Rosso's expertise) will be assessed by wireless functional near-infrared spectroscopy (fNIRS) of the PFC during challenged walking conditions (walking on an uneven surface and walking while reciting every other letter of the alphabet). fNIRS allows for real-time assessment of cortical activity while a participant is upright and moving by way of light-based measurements of changes in oxygenated and deoxygenated hemoglobin. Locomotor adaptation (Dr. Torres-Oviedo's expertise) will be evaluated with a split-belt walking protocol (i.e., legs moving at different speeds) that the investigators and others have used to robustly quantify motor adaptation capacity in older individuals and have shown to be reliant on cerebellar and basal ganglia function. The investigators will focus on two important aspects of locomotor adaptation that the investigators have quantified before: (Aim 1) rate at which individuals adapt to the new (split) walking environment and (Aim 2) capacity to transition between distinct walking patterns (i.e., the split-belt and the overground walking patterns), defined as motor switching. Adaptation rate and motor switching are quantified using step length asymmetry, which is the difference between a step length taken with one leg vs. the other. The investigators will focu
Conditions Studied
Interventions
- OTHER Split-belt walking
- OTHER Multiple transitions between split-belt and tied-belt walking
Study Locations (1)
Pennsylvania
- Sensorimotor Learning Laboratory, Schenley Place Suite 110 - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2021-11-08 |
| Est. Completion | 2026-06-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04934956
The ClinicalTrials.gov registry entry for NCT04934956 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 42 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pittsburgh, which has 1,238 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Community Mobility of Older Adults appearing as the primary indexed condition, and to 2 interventions - of which Split-belt walking is the first listed.
NCT04934956 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04934956 about?
NCT04934956 is a clinical study titled "Increasing Gait Automaticity in Older Adults by Exploiting Locomotor Adaptation". The investigators will test the following: 1) the extent of locomotor adaptation improvement in individuals aged 65 years and older; 2) the association between initial walking automaticity (i.e. less PFC activity while walking with a cognitive load) and prefrontal-subcortical function (measured via ...
What is the current status of trial NCT04934956?
This trial is currently recruiting. It is a NA study. The enrollment target is 42 participants. The study started on 2021-11-08. Estimated completion is 2026-06-01.
What conditions does trial NCT04934956 study?
This clinical trial studies the following conditions: Community Mobility of Older Adults, Locomotor Adaptability, Gait Automaticity.
What interventions are being tested in trial NCT04934956?
The interventions under investigation include: Split-belt walking (OTHER), Multiple transitions between split-belt and tied-belt walking (OTHER).
Who is sponsoring clinical trial NCT04934956?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04934956 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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