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NCT04912856 · ClinicalTrials.gov registry record · Phase 3
An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE
A Phase 3 study, sponsored by Xenon Pharmaceuticals.
- Terminated
- Registry status
- Phase 3
- Development phase
- 8
- Enrollment target
NCT04912856: Clinical Trial Phase 3 study, sponsored by Xenon Pharmaceuticals.
NCT04912856 is a Phase 3 study that was terminated before completion, run by Xenon Pharmaceuticals. The registered enrollment target is 8 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04912856, a Phase 3 study, was terminated before completion, sponsored by Xenon Pharmaceuticals.
- TERMINATED
- Registry status
- Phase 3
- Development phase
- 8 participants
- Enrollment target
Study Summary
To assess the long-term safety and tolerability of XEN496 in pediatric subjects with KCNQ2 developmental and epileptic encephalopathy (KCNQ2-DEE) who had participated in the primary study (XPF-009-301).
Primary Outcome
Safety and tolerability of XEN496 as assessed by incidence and severity of AEs and SAEs
Interventions
- DRUG XEN496
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2021-08-17 |
| Est. Completion | 2023-11-17 |
| Phase | Phase 3 |
Why NCT04912856 stopped before completion
NCT04912856 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which XEN496 is the first listed.
NCT04912856 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04912856 about?
NCT04912856 is a clinical study titled "An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE". To assess the long-term safety and tolerability of XEN496 in pediatric subjects with KCNQ2 developmental and epileptic encephalopathy (KCNQ2-DEE) who had participated in the primary study (XPF-009-301).
What is the current status of trial NCT04912856?
This trial is currently terminated. It is a Phase 3 study. The enrollment target is 8 participants. The study started on 2021-08-17. Estimated completion is 2023-11-17.
What interventions are being tested in trial NCT04912856?
The interventions under investigation include: XEN496 (DRUG).
Who is sponsoring clinical trial NCT04912856?
This trial is sponsored by Xenon Pharmaceuticals, which has 13 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04912856's enrollment target sits among peer trials
8 1993rd of 2000 higher than 6 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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