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NCT04906421 · ClinicalTrials.gov registry record · Phase 2
Study of TVB-2640 in Subjects With Nonalcoholic Steatohepatitis (NASH)
A Phase 2 study, sponsored by Sagimet Biosciences.
- Completed
- Registry status
- Phase 2
- Development phase
- 168
- Enrollment target
NCT04906421: Completed Phase 2 study, sponsored by Sagimet Biosciences.
NCT04906421 is a Phase 2 study that has completed, run by Sagimet Biosciences. The registered enrollment target is 168 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (26% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04906421, a Phase 2 study, has completed, sponsored by Sagimet Biosciences.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 168 participants
- Enrollment target
Study Summary
This is a Phase 2, multi-center, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy on TVB-2640 in subjects with non-alcoholic steatohepatitis (NASH). Subjects will be randomly assigned toTVB-2640 or matching placebo PO QD for 52 weeks, with the first dose administered on Day 1.
Primary Outcome
Histological improvement is defined as ≥2 points improvement in NAS with ≥1 point improvement in ballooning or inflammation
Interventions
- OTHER Placebo
- DRUG TVB-2640
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 168 participants |
| Start Date | 2021-08-12 |
| Est. Completion | 2023-10-02 |
| Phase | Phase 2 |
What the finished NCT04906421 record still lists
NCT04906421 is an interventional study that assigns participants to a tested intervention. The registered 168 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (26% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04906421 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04906421 about?
NCT04906421 is a clinical study titled "Study of TVB-2640 in Subjects With Nonalcoholic Steatohepatitis (NASH)". This is a Phase 2, multi-center, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy on TVB-2640 in subjects with non-alcoholic steatohepatitis (NASH). Subjects will be randomly assigned toTVB-2640 or matching placebo PO QD for 52 weeks, with the first dose adminis...
What is the current status of trial NCT04906421?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 168 participants. The study started on 2021-08-12. Estimated completion is 2023-10-02.
What interventions are being tested in trial NCT04906421?
The interventions under investigation include: Placebo (OTHER), TVB-2640 (DRUG).
Who is sponsoring clinical trial NCT04906421?
This trial is sponsored by Sagimet Biosciences, which has 7 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04906421's enrollment target sits among peer trials
168 403rd of 2000 higher than 1,595 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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