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NCT04884594 · ClinicalTrials.gov registry record · Phase 1
AAV8-hCocH for Cocaine Use Disorder
A Phase 1 study of Cocaine Dependence, in Remission, sponsored by W. Michael Hooten.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT04884594: Recruiting Phase 1 study of Cocaine Dependence, in Remission, sponsored by W. Michael Hooten.
NCT04884594 is a Phase 1 study of Cocaine Dependence, in Remission that is actively recruiting participants, run by W. Michael Hooten. The registered enrollment target is 10 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04884594, a Phase 1 study of Cocaine Dependence, in Remission, is actively recruiting participants, sponsored by W. Michael Hooten.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to test the safety of a novel gene viral vector treatment for adults with cocaine use disorder-sustained remission. This gene regulates an enzyme (cocaine hydrolase) that breaks down cocaine into inactive substances, thereby decreasing the pleasurable feeling this drug usually provides.
Primary Outcome
Number of participants with treatment-related adverse events
Conditions Studied
Interventions
- DRUG AAV8-hCocH
Study Locations (1)
Minnesota
- Mayo Clinic in Rochester - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2021-10-08 |
| Est. Completion | 2026-12 |
| Phase | Phase 1 |
What NCT04884594 shows while recruiting
NCT04884594 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower).
The record links to 1 condition, with Cocaine Dependence, in Remission appearing as the primary indexed condition, and to 1 intervention - of which AAV8-hCocH is the first listed.
NCT04884594 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT04884594 about?
NCT04884594 is a clinical study titled "AAV8-hCocH for Cocaine Use Disorder". The purpose of this study is to test the safety of a novel gene viral vector treatment for adults with cocaine use disorder-sustained remission. This gene regulates an enzyme (cocaine hydrolase) that breaks down cocaine into inactive substances, thereby decreasing the pleasurable feeling this drug u...
What is the current status of trial NCT04884594?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2021-10-08. Estimated completion is 2026-12.
What conditions does trial NCT04884594 study?
This clinical trial studies the following conditions: Cocaine Dependence, in Remission.
What interventions are being tested in trial NCT04884594?
The interventions under investigation include: AAV8-hCocH (DRUG).
Who is sponsoring clinical trial NCT04884594?
This trial is sponsored by W. Michael Hooten, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04884594 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Dependence, in Remission
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04884594's enrollment target sits among peer trials
10 1913th of 2000 higher than 46 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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