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NCT04865419 · ClinicalTrials.gov registry record · Phase 1
Study of AZD0466 Monotherapy or in Combination in Patients With Advanced Haematological Malignancies
A Phase 1 study, sponsored by AstraZeneca.
- Terminated
- Registry status
- Phase 1
- Development phase
- 46
- Enrollment target
NCT04865419: Clinical Trial Phase 1 study, sponsored by AstraZeneca.
NCT04865419 is a Phase 1 study that was terminated before completion, run by AstraZeneca. The registered enrollment target is 46 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (23% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04865419, a Phase 1 study, was terminated before completion, sponsored by AstraZeneca.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 46 participants
- Enrollment target
Study Summary
The purpose of the study is to the evaluate safety, tolerability, pharmacokinetics (PK), and efficacy of AZD0466 as monotherapy in partciapants with advanced haematological malignancies and also to assess drug-drug interaction (DDI) potential between AZD0466 and the azole antifungal voriconazole.
Primary Outcome
The safety and tolerability of AZD0466 in participants with advanced haematological malignancies were assessed.
Interventions
- DRUG Voriconazole
- DRUG AZD0466
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2021-06-11 |
| Est. Completion | 2023-08-08 |
| Phase | Phase 1 |
Why NCT04865419 stopped before completion
NCT04865419 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 46 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (23% lower).
The record links to 0 conditions, and to 2 interventions - of which Voriconazole is the first listed.
NCT04865419 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04865419 about?
NCT04865419 is a clinical study titled "Study of AZD0466 Monotherapy or in Combination in Patients With Advanced Haematological Malignancies". The purpose of the study is to the evaluate safety, tolerability, pharmacokinetics (PK), and efficacy of AZD0466 as monotherapy in partciapants with advanced haematological malignancies and also to assess drug-drug interaction (DDI) potential between AZD0466 and the azole antifungal voriconazole.
What is the current status of trial NCT04865419?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 46 participants. The study started on 2021-06-11. Estimated completion is 2023-08-08.
What interventions are being tested in trial NCT04865419?
The interventions under investigation include: Voriconazole (DRUG), AZD0466 (DRUG).
Who is sponsoring clinical trial NCT04865419?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04865419's enrollment target sits among peer trials
46 1058th of 2000 higher than 935 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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