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NCT04848064 · ClinicalTrials.gov registry record · Phase 1
Third-Party Natural Killer Cells and Mogamulizumab for the Treatment of Relapsed or Refractory Cutaneous T-cell Lymphomas or Adult T-Cell Leukemia/Lymphoma
A Phase 1 study of Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma and Recurrent Adult T-Cell Leukemia/Lymphoma, sponsored by John Reneau.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT04848064 is a Phase 1 study of Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma and Recurrent Adult T-Cell Leukemia/Lymphoma that is actively recruiting participants, run by John Reneau. The registered enrollment target is 12 participants, below the 59-participant average among 4 other Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04848064, a Phase 1 study of Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma and Recurrent Adult T-Cell Leukemia/Lymphoma, is actively recruiting participants, sponsored by John Reneau.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase I trial is to find out the best dose, possible benefits and/or side effects of third-party natural killer cells in combination with mogamulizumab in treating patients with cutaneous T-cell lymphoma or adult T-cell leukemia/lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Immunotherapy with third-party natural killer cells, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Mogamulizumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Giving third-party natural killer cells in combination with mogamulizumab may kill more cancer cells.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- OTHER Quality-of-Life Assessment
- BIOLOGICAL Natural Killer Cell Therapy
- BIOLOGICAL Mogamulizumab
Study Locations (1)
Ohio
- Ohio State University Comprehensive Cancer Center - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2022-05-06 |
| Est. Completion | 2027-01-30 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04848064
The ClinicalTrials.gov registry entry for NCT04848064 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 59-participant average among 4 other Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma trials with a reported enrollment target (80% lower). The listed sponsor is John Reneau, which has 2 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma appearing as the primary indexed condition, and to 5 interventions - of which Cyclophosphamide is the first listed.
NCT04848064 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.
Frequently Asked Questions
What is clinical trial NCT04848064 about?
NCT04848064 is a clinical study titled "Third-Party Natural Killer Cells and Mogamulizumab for the Treatment of Relapsed or Refractory Cutaneous T-cell Lymphomas or Adult T-Cell Leukemia/Lymphoma". This phase I trial is to find out the best dose, possible benefits and/or side effects of third-party natural killer cells in combination with mogamulizumab in treating patients with cutaneous T-cell lymphoma or adult T-cell leukemia/lymphoma that has come back (relapsed) or does not respond to trea...
What is the current status of trial NCT04848064?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2022-05-06. Estimated completion is 2027-01-30.
What conditions does trial NCT04848064 study?
This clinical trial studies the following conditions: Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma, Recurrent Adult T-Cell Leukemia/Lymphoma, Refractory Adult T-Cell Leukemia/Lymphoma, Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma.
What interventions are being tested in trial NCT04848064?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Quality-of-Life Assessment (OTHER), Natural Killer Cell Therapy (BIOLOGICAL), Mogamulizumab (BIOLOGICAL).
Who is sponsoring clinical trial NCT04848064?
This trial is sponsored by John Reneau, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04848064 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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