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NCT04828135 · ClinicalTrials.gov registry record · Phase 2
Dual MRI for Cardiopulmonary COVID-19 Long Haulers
A Phase 2 study, sponsored by Bastiaan Driehuys.
- Completed
- Registry status
- Phase 2
- Development phase
- 18
- Enrollment target
NCT04828135 is a Phase 2 study that has completed, run by Bastiaan Driehuys. The registered enrollment target is 18 participants.
The verdict
NCT04828135, a Phase 2 study, has completed, sponsored by Bastiaan Driehuys.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 18 participants
- Enrollment target
Study Summary
The next phase of the COVID-19 pandemic is likely to see a surge in an associated chronic cardiopulmonary disease that will challenge health systems. Recovered patients are presenting with persistent dyspnea at the Duke Pulmonary Post-COVID clinic. Evidence is now mounting that recovered patients have significant residual pulmonary disease, while myocardial injury has also been increasingly reported. To optimally care for these patients, Duke Pulmonary study team must comprehensively assess and monitor the changes in cardiopulmonary function and relate the changes to physiologic and quality of life outcomes. The study team will deploy cutting-edge MRI to fully characterize cardiopulmonary function in enrolled 30 subjects (accrual 23 subjects) at time point 60-120 days post recovery and 6-9 months later. Cardiac MRI will assess the myocardial status and right ventricular function, while hyperpolarized 129Xe MRI will provide a 3D assessment of pulmonary ventilation, interstitial barrier integrity, and pulmonary vascular hemodynamics. The overall objective outlined in this study is to demonstrate the feasibility and value of comprehensive longitudinal imaging characterization of cardiopulmonary structure and function in patients recovered from Covid-19.
Interventions
- DRUG Hyperpolarized 129Xenon gas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2021-05-26 |
| Est. Completion | 2023-04-20 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04828135
The ClinicalTrials.gov registry entry for NCT04828135 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 18 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bastiaan Driehuys, which has 16 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Hyperpolarized 129Xenon gas is the first listed.
NCT04828135 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04828135 about?
NCT04828135 is a clinical study titled "Dual MRI for Cardiopulmonary COVID-19 Long Haulers". The next phase of the COVID-19 pandemic is likely to see a surge in an associated chronic cardiopulmonary disease that will challenge health systems. Recovered patients are presenting with persistent dyspnea at the Duke Pulmonary Post-COVID clinic. Evidence is now mounting that recovered patients ha...
What is the current status of trial NCT04828135?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 18 participants. The study started on 2021-05-26. Estimated completion is 2023-04-20.
What interventions are being tested in trial NCT04828135?
The interventions under investigation include: Hyperpolarized 129Xenon gas (DRUG).
Who is sponsoring clinical trial NCT04828135?
This trial is sponsored by Bastiaan Driehuys, which has 16 total clinical trials registered on ClinicalTrials.gov.
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