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NCT04784390 · ClinicalTrials.gov registry record · Phase 1
Proof of Concept Study of Binocular Videogames Versus Patching for Amblyopia
A Phase 1 study, sponsored by Novartis Pharmaceuticals.
- Terminated
- Registry status
- Phase 1
- Development phase
- 27
- Enrollment target
NCT04784390: Clinical Trial Phase 1 study, sponsored by Novartis Pharmaceuticals.
NCT04784390 is a Phase 1 study that was terminated before completion, run by Novartis Pharmaceuticals. The registered enrollment target is 27 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04784390, a Phase 1 study, was terminated before completion, sponsored by Novartis Pharmaceuticals.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 27 participants
- Enrollment target
Study Summary
The purpose of this PoC study was to evaluate the potential therapeutic efficacy of binocular video games played on a tablet and to compare the efficacy of binocular video games versus patching in amblyopic patients 4 to 7 years old (Part A) as well as to gain experience with binocular video games in older children population of 8 to12 years old (Part B). Part A and Part B was designed to provide long term data on durability of binocular video games treatment. The study consisted of two parts, Part A: randomized, single masked PoC study in children 4 to 7 years old at Screening, and Part B: open-label substudy in children 8 to 12 year old at Screening.
Primary Outcome
Part A: Best corrected visual acuity (BCVA) in the amblyopic eye will be measured via mixed model repeated measures (MMRM).
Interventions
- DEVICE Binocular video games
- DEVICE Patching of the sound eye
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2021-06-30 |
| Est. Completion | 2022-08-03 |
| Phase | Phase 1 |
Why NCT04784390 stopped before completion
NCT04784390 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 2 interventions - of which Binocular video games is the first listed.
NCT04784390 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04784390 about?
NCT04784390 is a clinical study titled "Proof of Concept Study of Binocular Videogames Versus Patching for Amblyopia". The purpose of this PoC study was to evaluate the potential therapeutic efficacy of binocular video games played on a tablet and to compare the efficacy of binocular video games versus patching in amblyopic patients 4 to 7 years old (Part A) as well as to gain experience with binocular video games i...
What is the current status of trial NCT04784390?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 27 participants. The study started on 2021-06-30. Estimated completion is 2022-08-03.
What interventions are being tested in trial NCT04784390?
The interventions under investigation include: Binocular video games (DEVICE), Patching of the sound eye (DEVICE).
Who is sponsoring clinical trial NCT04784390?
This trial is sponsored by Novartis Pharmaceuticals, which has 1,375 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04784390's enrollment target sits among peer trials
27 1463rd of 2000 higher than 519 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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