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NCT04774848 · ClinicalTrials.gov registry record · NA
High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia
A NA study of Congenital Diaphragmatic Hernia, sponsored by University of Utah.
- Recruiting
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 2
- Study locations
NCT04774848: Recruiting NA study of Congenital Diaphragmatic Hernia, sponsored by University of Utah.
NCT04774848 is a NA study of Congenital Diaphragmatic Hernia that is actively recruiting participants, run by University of Utah. The registered enrollment target is 50 participants, below the 194-participant average among 22 other Congenital Diaphragmatic Hernia trials with a reported enrollment target (74% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04774848, a NA study of Congenital Diaphragmatic Hernia, is actively recruiting participants, sponsored by University of Utah.
- RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this study is to conduct a prospective study of all congenital diaphragmatic hernia (CDH) neonates managed at the University of Utah newborn intensive care unit (NICU) and Primary Children's Hospital NICU that required mechanical ventilation at birth. As both high frequency jet ventilation (HFJV) and high frequency oscillatory ventilation (HFOV) are standard approaches to ventilatory support of all neonates including CDH, CDH infants will be randomized at the time of birth or admission to either HFJV or HFOV as initial ventilator mode, stratified by position of the liver in the abdomen or thorax (if known) by 24 hours of age. Measures of oxygenation, ventilation and hemodynamics of the CDH cohort managed on HFOV compared to those on HFJV.
Primary Outcome
The OI will be measured at 24 hours of age using a standard of care arterial blood gas and oxygen settings. These measurements will then be compared between the stratified groups
Conditions Studied
Interventions
- DEVICE High Frequency Jet Ventilator
- DEVICE High Frequency Oscillatory Ventilator
Study Locations (2)
Utah
- Primary Children's Hospital - Salt Lake City
- University Hospital - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2020-12-30 |
| Est. Completion | 2025-08-28 |
| Phase | NA |
What NCT04774848 shows while recruiting
NCT04774848 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 194-participant average among 22 other Congenital Diaphragmatic Hernia trials with a reported enrollment target (74% lower).
The record links to 1 condition, with Congenital Diaphragmatic Hernia appearing as the primary indexed condition, and to 2 interventions - of which High Frequency Jet Ventilator is the first listed.
NCT04774848 reports a single indexed study location in Utah.
Frequently Asked Questions
What is clinical trial NCT04774848 about?
NCT04774848 is a clinical study titled "High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia". The purpose of this study is to conduct a prospective study of all congenital diaphragmatic hernia (CDH) neonates managed at the University of Utah newborn intensive care unit (NICU) and Primary Children's Hospital NICU that required mechanical ventilation at birth. As both high frequency jet ventil...
What is the current status of trial NCT04774848?
This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2020-12-30. Estimated completion is 2025-08-28.
What conditions does trial NCT04774848 study?
This clinical trial studies the following conditions: Congenital Diaphragmatic Hernia.
What interventions are being tested in trial NCT04774848?
The interventions under investigation include: High Frequency Jet Ventilator (DEVICE), High Frequency Oscillatory Ventilator (DEVICE).
Who is sponsoring clinical trial NCT04774848?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04774848 being conducted?
This trial has 2 study locations across Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Congenital Diaphragmatic Hernia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04774848's enrollment target sits among peer trials
50 8th of 22 higher than 15 of 22 other Congenital Diaphragmatic Hernia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Congenital Diaphragmatic Hernia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)
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-
Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH)
RECRUITING · NA
-
Safety and Efficacy of FETO in CDH: A Phase III Trial
RECRUITING · NA
-
Trial of FETO for Severe Congenital Diaphragmatic Hernia
RECRUITING · NA
-
Fetal Endoscopic Tracheal Occlusion for CDH (CDH)
RECRUITING · NA
-
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO)
RECRUITING · NA
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