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NCT04764162 · ClinicalTrials.gov registry record · NA
Choline and Cardiometabolic Health
A NA study, sponsored by Virginia Polytechnic Institute and State University.
- Completed
- Registry status
- NA
- Development phase
- 14
- Enrollment target
NCT04764162 is a NA study that has completed, run by Virginia Polytechnic Institute and State University. The registered enrollment target is 14 participants.
The verdict
NCT04764162, a NA study, has completed, sponsored by Virginia Polytechnic Institute and State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 14 participants
- Enrollment target
Study Summary
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular disease (CVD) risk in some but not all cohort studies. The relevance of observations in animals to humans is unclear and little information is available on the mechanisms linking TMAO to increased CVD risk. Vascular dysfunction plays a critical role in the initiation and progression of atherothrombotic disease. Whether TMAO impairs vascular function in humans is not known. The purpose of this study is to determine if short term supplementation of dietary choline, which increases TMAO, affects CVD risk factors, such as glucose homeostasis and vascular function.
Interventions
- DIETARY_SUPPLEMENT Placebo
- DIETARY_SUPPLEMENT Choline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2021-08-20 |
| Est. Completion | 2023-11-21 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04764162
The ClinicalTrials.gov registry entry for NCT04764162 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Virginia Polytechnic Institute and State University, which has 104 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04764162 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04764162 about?
NCT04764162 is a clinical study titled "Choline and Cardiometabolic Health". Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular disease (CVD) risk in some but not all cohort studies. The relevance of obs...
What is the current status of trial NCT04764162?
This trial is currently completed. It is a NA study. The enrollment target is 14 participants. The study started on 2021-08-20. Estimated completion is 2023-11-21.
What interventions are being tested in trial NCT04764162?
The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), Choline (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04764162?
This trial is sponsored by Virginia Polytechnic Institute and State University, which has 104 total clinical trials registered on ClinicalTrials.gov.
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