Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04748055 · ClinicalTrials.gov registry record
Examining Changes in Nasal IL-1 During Acute Asthma Exacerbation in Adolescents
A clinical trial, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- 40
- Enrollment target
NCT04748055: Completed study, sponsored by University of North Carolina, Chapel Hill.
NCT04748055 is a clinical trial that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 40 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04748055 has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- 40 participants
- Enrollment target
Study Summary
To study the change from baseline in IL-1β (interleukin 1 beta) concentrations in the nasal airway during acute asthma exacerbation, specifically to measure the degree of change and identify the timing of peak IL-1β concentration. This information will allow the investigators to estimate effect size and guide decisions about the optimal timing of anakinra administration for the future study.
Primary Outcome
Nasal epithelial lining fluid (NELF) is collected during a period of wellness (baseline) and daily during acute asthma exacerbation (defined by pre-specified criteria) for 5 days. This outcome is defined as the percent change from baseline in nasal IL-1β concentration during acute asthma exacerbation, calculated by comparing the peak concentration observed during the exacerbation to the baseline concentration (i.e., \[(peak value of IL-1β during exacerbation - baseline value of IL-1β)/baseline v
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2021-07-27 |
| Est. Completion | 2024-02-08 |
What the finished NCT04748055 record still lists
NCT04748055 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT04748055 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04748055 about?
NCT04748055 is a clinical study titled "Examining Changes in Nasal IL-1 During Acute Asthma Exacerbation in Adolescents". To study the change from baseline in IL-1β (interleukin 1 beta) concentrations in the nasal airway during acute asthma exacerbation, specifically to measure the degree of change and identify the timing of peak IL-1β concentration. This information will allow the investigators to estimate effect size...
What is the current status of trial NCT04748055?
This trial is currently completed. The enrollment target is 40 participants. The study started on 2021-07-27. Estimated completion is 2024-02-08.
Who is sponsoring clinical trial NCT04748055?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01306019 · 40 participants · Phase 1
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
- NCT01608152 · 40 participants
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
- NCT01668082 · 40 participants · NA
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection
- NCT02015013 · 40 participants · Phase 2
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI