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NCT04739761 · ClinicalTrials.gov registry record · Phase 3
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
A Phase 3 study of Breast Cancer, sponsored by AstraZeneca.
- Active
- Registry status
- Phase 3
- Development phase
- 506
- Enrollment target
- 20
- Study locations
NCT04739761 is a Phase 3 study of Breast Cancer that is active but no longer recruiting, run by AstraZeneca. The registered enrollment target is 506 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (82% lower). The trial reports 20 study locations across 5 states.
The verdict
NCT04739761, a Phase 3 study of Breast Cancer, is active but no longer recruiting, sponsored by AstraZeneca.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 506 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is open-label, multicenter, international study, assessing the efficacy and safety of Trastuzumab deruxtecan (T-DXd) in participants with or without brain metastasis (BMs), with previously-treated advanced/metastatic HER2-positive breast cancer whose disease has progressed on prior anti-HER2-based regimens and who received no more than 2 lines/regimens of therapy in the metastatic setting (excluding tucatinib).
Conditions Studied
Interventions
- DRUG Trastuzumab Deruxtecan
Study Locations (20)
Other
- Research Site - Adelaide
- Research Site - Auchenflower
- Research Site - Clayton
- Research Site - Heidelberg
- Research Site - St Leonards
- Research Site - Subiaco
- Research Site - Anderlecht
- Research Site - Bruges
- Research Site - Leuven
- Research Site - Liège
- Research Site - Copenhagen
- Research Site - Herlev
- Research Site - Odense C
- Research Site - Helsinki
- Research Site - Tampere
- Research Site - Turku
Massachusetts
- Research Site - Boston
North Carolina
- Research Site - Durham
British Columbia
- Research Site - Vancouver
Ontario
- Research Site - Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 506 participants |
| Start Date | 2021-06-22 |
| Est. Completion | 2026-05-26 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04739761
The ClinicalTrials.gov registry entry for NCT04739761 describes a study currently listed as active not recruiting, categorized as Phase 3. The registered enrollment target is 506 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (82% lower). The listed sponsor is AstraZeneca, which has 1,285 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Breast Cancer appearing as the primary indexed condition, and to 1 intervention - of which Trastuzumab Deruxtecan is the first listed.
NCT04739761 reports 20 study locations spanning 5 distinct geographic areas - top geographies include Other, Massachusetts, North Carolina.
Frequently Asked Questions
What is clinical trial NCT04739761 about?
NCT04739761 is a clinical study titled "A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer". This is open-label, multicenter, international study, assessing the efficacy and safety of Trastuzumab deruxtecan (T-DXd) in participants with or without brain metastasis (BMs), with previously-treated advanced/metastatic HER2-positive breast cancer whose disease has progressed on prior anti-HER2-ba...
What is the current status of trial NCT04739761?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 506 participants. The study started on 2021-06-22. Estimated completion is 2026-05-26.
What conditions does trial NCT04739761 study?
This clinical trial studies the following conditions: Breast Cancer.
What interventions are being tested in trial NCT04739761?
The interventions under investigation include: Trastuzumab Deruxtecan (DRUG).
Who is sponsoring clinical trial NCT04739761?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04739761 being conducted?
This trial has 20 study locations across Massachusetts, North Carolina, British Columbia, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.