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NCT04731714 · ClinicalTrials.gov registry record · NA
Median Nerve Stimulation Pilot
A NA study, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- NA
- Development phase
- 34
- Enrollment target
NCT04731714: Completed NA study, sponsored by Washington University School of Medicine.
NCT04731714 is a NA study that has completed, run by Washington University School of Medicine. The registered enrollment target is 34 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04731714, a NA study, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
Study Summary
Results from the University of Nottingham suggested that rhythmic median nerve stimulation (MNS) improves tic symptoms in Tourette syndrome (TS). The investigators will (1) provide a first replication of their study, (2) test the hypothesized electrophysiological mechanism and rule out a placebo effect as cause for the symptomatic benefit, and (3) gather information on the duration of effect after the end of stimulation and on individual characteristics that predict improvement with simulation. Completion of these Aims will give a clear go/no-go signal for a future clinical trial of chronic MNS delivered by a yet-to-be-developed wristwatch-style device. NOTE: This study is not intended to evaluate a specific device for future use. Rather it is a study to determine the action of pulsed electrical stimulation on tic symptoms and to gain early evidence of effectiveness. This is a non-significant risk device study.
Primary Outcome
The number of tics per minute is assessed by an expert rater blind to condition and time point. Mean tic frequency was compared in on vs. off 1-minute stimulation epochs on the rhythmic MNS day. This analysis replicates that of Study 3 in the Morera Maiquez et al 2020 citation, who reported tics in the last 40 seconds of the block to minimize carryover effects. A Mixed Models Analysis was used to test statistical significance; it included a factor for possible within-day carryover effect and use
Interventions
- DEVICE Rhythmic median nerve stimulation
- DEVICE Arrhythmic median nerve stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2021-07-15 |
| Est. Completion | 2022-04-27 |
| Phase | NA |
What the finished NCT04731714 record still lists
NCT04731714 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Rhythmic median nerve stimulation is the first listed.
NCT04731714 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04731714 about?
NCT04731714 is a clinical study titled "Median Nerve Stimulation Pilot". Results from the University of Nottingham suggested that rhythmic median nerve stimulation (MNS) improves tic symptoms in Tourette syndrome (TS). The investigators will (1) provide a first replication of their study, (2) test the hypothesized electrophysiological mechanism and rule out a placebo eff...
What is the current status of trial NCT04731714?
This trial is currently completed. It is a NA study. The enrollment target is 34 participants. The study started on 2021-07-15. Estimated completion is 2022-04-27.
What interventions are being tested in trial NCT04731714?
The interventions under investigation include: Rhythmic median nerve stimulation (DEVICE), Arrhythmic median nerve stimulation (DEVICE).
Who is sponsoring clinical trial NCT04731714?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04731714's enrollment target sits among peer trials
34 1570th of 2000 higher than 427 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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