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NCT04726085 · ClinicalTrials.gov registry record · NA
Ibuprofen Versus Indomethacin Following Emergent Cerclage Placement
A NA study, sponsored by Woman's.
- Terminated
- Registry status
- NA
- Development phase
- 11
- Enrollment target
NCT04726085: Clinical Trial NA study, sponsored by Woman's.
NCT04726085 is a NA study that was terminated before completion, run by Woman's. The registered enrollment target is 11 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04726085, a NA study, was terminated before completion, sponsored by Woman's.
- TERMINATED
- Registry status
- NA
- Development phase
- 11 participants
- Enrollment target
Study Summary
Cervical insufficiency is defined as painless cervical dilation in the second trimester. Cervical insufficiency can ultimately lead to second trimester loss of pregnancy. Cerclages are utilized in pregnancies affected by cervical insufficiency in order to prolong gestational latency. There have been several studies investigating the efficacy of perioperative medications for cerclage placement and the effects they have on gestational latency. Some such studies have found that perioperative indomethacin in combination with antibiotics have significantly increased gestational latency when compared to placebo. Indomethacin has traditionally been the tocolytic of choice with cerclage placement. At our hospital, ibuprofen has been the tocolytic of choice for cerclage placement secondary to pharmacy availability. Our study aims to evaluate whether gestational latency differs among patients undergoing emergent cerclage whether they receive perioperative ibuprofen or indomethacin.
Primary Outcome
Days from cerclage placement to delivery, assessed up to 26 weeks
Interventions
- DRUG Indomethacin 150mg
- DRUG Ibuprofen 2400mg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2021-02-01 |
| Est. Completion | 2023-11-06 |
| Phase | NA |
Why NCT04726085 stopped before completion
NCT04726085 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 11 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Indomethacin 150mg is the first listed.
NCT04726085 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04726085 about?
NCT04726085 is a clinical study titled "Ibuprofen Versus Indomethacin Following Emergent Cerclage Placement". Cervical insufficiency is defined as painless cervical dilation in the second trimester. Cervical insufficiency can ultimately lead to second trimester loss of pregnancy. Cerclages are utilized in pregnancies affected by cervical insufficiency in order to prolong gestational latency. There have been...
What is the current status of trial NCT04726085?
This trial is currently terminated. It is a NA study. The enrollment target is 11 participants. The study started on 2021-02-01. Estimated completion is 2023-11-06.
What interventions are being tested in trial NCT04726085?
The interventions under investigation include: Indomethacin 150mg (DRUG), Ibuprofen 2400mg (DRUG).
Who is sponsoring clinical trial NCT04726085?
This trial is sponsored by Woman's, which has 17 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04726085's enrollment target sits among peer trials
11 1927th of 2000 higher than 74 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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