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NCT04696471 · ClinicalTrials.gov registry record · NA
Effects of Theta Burst Stimulation on the Brain, Behavior, and Clinical Symptoms in Adults With Bipolar Disorder
A NA study, sponsored by Mary Phillips, MD MD (Cantab).
- Completed
- Registry status
- NA
- Development phase
- 146
- Enrollment target
NCT04696471: Completed NA study, sponsored by Mary Phillips, MD MD (Cantab).
NCT04696471 is a NA study that has completed, run by Mary Phillips, MD MD (Cantab). The registered enrollment target is 146 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (90% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04696471, a NA study, has completed, sponsored by Mary Phillips, MD MD (Cantab).
- COMPLETED
- Registry status
- NA
- Development phase
- 146 participants
- Enrollment target
Study Summary
Bipolar Disorder (BD) is a common and highly debilitating psychiatric disorder, however, the predisposing brain mechanisms are poorly understood. Here, the investigators aim to examine the immediate effect of transcranial brain stimulation (TBS) on brain activity and emotions in adults with and without BD as a first stage toward understanding the predisposing brain mechanisms of BD. The investigators hypothesize that TBS will reduce brain activity while playing a game with rewards in all adults, but the TBS will reduce brain activity more in the adults with BD compared to adults without BD. Furthermore, the investigators hypothesize that this reduced brain activity will be associated with reduced BD symptoms, such as negative emotions.
Primary Outcome
The difference in magnitude between pre and post cTBS scans for each cTBS condition of the extracted blood oxygen level-dependent (BOLD) signal from the left ventrolateral prefrontal cortex to the uncertain reward expectancy regressor during performance of the reward task
Interventions
- DEVICE Continuous Theta Burst Stimulation (cTBS)
- DEVICE Sham Continuous Theta Burst Stimulation (Sham cTBS)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 146 participants |
| Start Date | 2021-04-06 |
| Est. Completion | 2025-10-24 |
| Phase | NA |
What the finished NCT04696471 record still lists
NCT04696471 is an interventional study that assigns participants to a tested intervention. The registered 146 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (90% lower).
The record links to 0 conditions, and to 2 interventions - of which Continuous Theta Burst Stimulation (cTBS) is the first listed.
NCT04696471 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04696471 about?
NCT04696471 is a clinical study titled "Effects of Theta Burst Stimulation on the Brain, Behavior, and Clinical Symptoms in Adults With Bipolar Disorder". Bipolar Disorder (BD) is a common and highly debilitating psychiatric disorder, however, the predisposing brain mechanisms are poorly understood. Here, the investigators aim to examine the immediate effect of transcranial brain stimulation (TBS) on brain activity and emotions in adults with and with...
What is the current status of trial NCT04696471?
This trial is currently completed. It is a NA study. The enrollment target is 146 participants. The study started on 2021-04-06. Estimated completion is 2025-10-24.
What interventions are being tested in trial NCT04696471?
The interventions under investigation include: Continuous Theta Burst Stimulation (cTBS) (DEVICE), Sham Continuous Theta Burst Stimulation (Sham cTBS) (DEVICE).
Who is sponsoring clinical trial NCT04696471?
This trial is sponsored by Mary Phillips, MD MD (Cantab), which has 3 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04696471's enrollment target sits among peer trials
146 704th of 2000 higher than 1,296 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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