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NCT04691622 · ClinicalTrials.gov registry record · Phase 1
Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts
A Phase 1 study of Viral Infection and Hematopoietic Stem Cell Transplantation (HSCT), sponsored by Children's National Research Institute.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 48
- Enrollment target
- 3
- Study locations
NCT04691622 is a Phase 1 study of Viral Infection and Hematopoietic Stem Cell Transplantation (HSCT) that is actively recruiting participants, run by Children's National Research Institute. The registered enrollment target is 48 participants, below the 225-participant average among 11 other Viral Infection trials with a reported enrollment target (79% lower). The trial reports 3 study locations across 2 states.
The verdict
NCT04691622, a Phase 1 study of Viral Infection and Hematopoietic Stem Cell Transplantation (HSCT), is actively recruiting participants, sponsored by Children's National Research Institute.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 48 participants
- Enrollment target
- 3
- Study locations
Study Summary
This is a Phase I dose-escalation study to evaluate the safety of norovirus -specific T-cell (NST) therapy for chronic norovirus infection in participants following hematopoietic stem cell transplantation (HSCT) or who are immunocompromised due to PID and have not undergone HSCT, or Solid Organ Transplant (SOT) recipients.
Conditions Studied
Interventions
- BIOLOGICAL Norovirus -specific T-cell (NST) therapy
Study Locations (3)
Maryland
- Johns Hopkins University - Baltimore
- National Institutes of Health (NIH) - Bethesda
District of Columbia
- Children's National Hospital - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2022-03-17 |
| Est. Completion | 2028-10-30 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04691622
The ClinicalTrials.gov registry entry for NCT04691622 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 225-participant average among 11 other Viral Infection trials with a reported enrollment target (79% lower). The listed sponsor is Children's National Research Institute, which has 92 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Viral Infection appearing as the primary indexed condition, and to 1 intervention - of which Norovirus -specific T-cell (NST) therapy is the first listed.
NCT04691622 reports 3 study locations spanning 2 distinct geographic areas - top geographies include Maryland, District of Columbia.
Frequently Asked Questions
What is clinical trial NCT04691622 about?
NCT04691622 is a clinical study titled "Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts". This is a Phase I dose-escalation study to evaluate the safety of norovirus -specific T-cell (NST) therapy for chronic norovirus infection in participants following hematopoietic stem cell transplantation (HSCT) or who are immunocompromised due to PID and have not undergone HSCT, or Solid Organ Tran...
What is the current status of trial NCT04691622?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 48 participants. The study started on 2022-03-17. Estimated completion is 2028-10-30.
What conditions does trial NCT04691622 study?
This clinical trial studies the following conditions: Viral Infection, Hematopoietic Stem Cell Transplantation (HSCT), Primary Immunodeficiency Disorders (PID).
What interventions are being tested in trial NCT04691622?
The interventions under investigation include: Norovirus -specific T-cell (NST) therapy (BIOLOGICAL).
Who is sponsoring clinical trial NCT04691622?
This trial is sponsored by Children's National Research Institute, which has 92 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04691622 being conducted?
This trial has 3 study locations across District of Columbia, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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