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NCT04684706 · ClinicalTrials.gov registry record · NA
Compressed Intermittent Theta Burst Stimulation
A NA study of Treatment-Resistant Depression, sponsored by University of Pennsylvania.
- Active
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 2
- Study locations
NCT04684706: Active NA study of Treatment-Resistant Depression, sponsored by University of Pennsylvania.
NCT04684706 is a NA study of Treatment-Resistant Depression that is active but no longer recruiting, run by University of Pennsylvania. The registered enrollment target is 40 participants, below the 373-participant average among 54 other Treatment-Resistant Depression trials with a reported enrollment target (89% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04684706, a NA study of Treatment-Resistant Depression, is active but no longer recruiting, sponsored by University of Pennsylvania.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 2
- Study locations
Study Summary
In this proposal the investigators will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory depression. This protocol will build on a previously published study demonstrating clinical efficacy of intermittent theta-burst stimulation (iTBS) on left dorsolateral prefrontal cortex (L-dlPFC) in a treatment refractory population.
Primary Outcome
Depressive symptoms will be measured before and after treatment by means of the clinician-administered Montgomery Asberg Depression Rating Scale (MADRS) (0-60, lower scores indicate lower depressive symptoms) and the self report Beck Depression Inventory (BDI II) (0-30, lower scores indicate lower depressive symptoms). Change will be measured by comparing measurements pre- and post- on the same measures. The bigger the change, the bigger the reduction in depressive symptoms.
Conditions Studied
Interventions
- DEVICE intermittent Theta Burst Stimulation
Study Locations (2)
California
- Department of Interventional Psychiatry, University of California San Diego - La Jolla
Pennsylvania
- Center for Neuromodulation in Depression and Stress - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2020-02-20 |
| Est. Completion | 2027-01-20 |
| Phase | NA |
What the registry record for NCT04684706 still lists
NCT04684706 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 373-participant average among 54 other Treatment-Resistant Depression trials with a reported enrollment target (89% lower).
The record links to 1 condition, with Treatment-Resistant Depression appearing as the primary indexed condition, and to 1 intervention - of which intermittent Theta Burst Stimulation is the first listed.
NCT04684706 reports a single indexed study location in California, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04684706 about?
NCT04684706 is a clinical study titled "Compressed Intermittent Theta Burst Stimulation". In this proposal the investigators will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory depression. This protocol will build on a previous...
What is the current status of trial NCT04684706?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2020-02-20. Estimated completion is 2027-01-20.
What conditions does trial NCT04684706 study?
This clinical trial studies the following conditions: Treatment-Resistant Depression.
What interventions are being tested in trial NCT04684706?
The interventions under investigation include: intermittent Theta Burst Stimulation (DEVICE).
Who is sponsoring clinical trial NCT04684706?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04684706 being conducted?
This trial has 2 study locations across California, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Treatment-Resistant Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04684706's enrollment target sits among peer trials
40 32nd of 54 higher than 21 of 54 other Treatment-Resistant Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Treatment-Resistant Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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PCS in Severe Treatment Resistant Depression
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Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
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