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NCT04670510 · ClinicalTrials.gov registry record · NA
Fitness for Brain Optimization for Late-Life Depression
A NA study, sponsored by University of Pittsburgh.
- Completed
- Registry status
- NA
- Development phase
- 46
- Enrollment target
NCT04670510: Completed NA study, sponsored by University of Pittsburgh.
NCT04670510 is a NA study that has completed, run by University of Pittsburgh. The registered enrollment target is 46 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04670510, a NA study, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- NA
- Development phase
- 46 participants
- Enrollment target
Study Summary
Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with remitted LLD. This will generate preliminary data regarding neural targets of aerobic exercise training that may translate to cognitive benefits in those with rLLD, a population who remains at high risk for dementia despite successful treatment of depression.
Primary Outcome
Cardiorespiratory fitness will be measured via a cardiopulmonary exercise test (CPET) indicated by maximal VO2 on a motorized treadmill. while measuring oxygen utilization via Parvo Medics True one metabolic cart. The test follows a modified Balke protocol in which speed remains constant with the intensity being increased every two minutes via a raise of 2.0% of the incline. The speed was an agreed upon speed between participant and staff (between 2.0 and 4.0 mph). The test will conclude when th
Interventions
- OTHER On-site AE
- OTHER At-home AE
- OTHER Social Engagement (SE)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2021-08-04 |
| Est. Completion | 2025-10-22 |
| Phase | NA |
What the finished NCT04670510 record still lists
NCT04670510 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 46 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 3 interventions - of which On-site AE is the first listed.
NCT04670510 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04670510 about?
NCT04670510 is a clinical study titled "Fitness for Brain Optimization for Late-Life Depression". Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits ...
What is the current status of trial NCT04670510?
This trial is currently completed. It is a NA study. The enrollment target is 46 participants. The study started on 2021-08-04. Estimated completion is 2025-10-22.
What interventions are being tested in trial NCT04670510?
The interventions under investigation include: On-site AE (OTHER), At-home AE (OTHER), Social Engagement (SE) (OTHER).
Who is sponsoring clinical trial NCT04670510?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04670510's enrollment target sits among peer trials
46 1402nd of 2000 higher than 590 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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