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NCT04652518 · ClinicalTrials.gov registry record · Phase 2
LYT-100 in Post-acute COVID-19 Respiratory Disease
A Phase 2 study, sponsored by PureTech.
- Terminated
- Registry status
- Phase 2
- Development phase
- 185
- Enrollment target
NCT04652518: Clinical Trial Phase 2 study, sponsored by PureTech.
NCT04652518 is a Phase 2 study that was terminated before completion, run by PureTech. The registered enrollment target is 185 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (39% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04652518, a Phase 2 study, was terminated before completion, sponsored by PureTech.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 185 participants
- Enrollment target
Study Summary
This study is being conducted in two parts, A and B. Part A is a randomized, double-blind, parallel arm study to evaluate the safety and efficacy of LYT-100 compared to placebo in adults with post-acute COVID-19 respiratory complications. Part B is an Open Label Extension (OLE) study for patients who complete Part A.
Primary Outcome
The 6MWT is a validated endpoint commonly used in clinical trial research. The 6MWT measures the distance a subject can quickly walk on a flat, hard surface in a period of 6 minutes. It evaluates the global and integrated response of all the systems involved during exercise.
Interventions
- OTHER Placebo
- DRUG LYT-100
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 185 participants |
| Start Date | 2020-12-11 |
| Est. Completion | 2022-07-18 |
| Phase | Phase 2 |
Why NCT04652518 stopped before completion
NCT04652518 is an interventional study that assigns participants to a tested intervention. The registered 185 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (39% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04652518 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04652518 about?
NCT04652518 is a clinical study titled "LYT-100 in Post-acute COVID-19 Respiratory Disease". This study is being conducted in two parts, A and B. Part A is a randomized, double-blind, parallel arm study to evaluate the safety and efficacy of LYT-100 compared to placebo in adults with post-acute COVID-19 respiratory complications. Part B is an Open Label Extension (OLE) study for patients wh...
What is the current status of trial NCT04652518?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 185 participants. The study started on 2020-12-11. Estimated completion is 2022-07-18.
What interventions are being tested in trial NCT04652518?
The interventions under investigation include: Placebo (OTHER), LYT-100 (DRUG).
Who is sponsoring clinical trial NCT04652518?
This trial is sponsored by PureTech, which has 6 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04652518's enrollment target sits among peer trials
185 357th of 2000 higher than 1,641 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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