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Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer
NCT04592913 · View on ClinicalTrials.gov ↗
Study Summary
This is a Global Study of Neoadjuvant-Adjuvant Durvalumab or Placebo and FLOT Chemotherapy Followed by Adjuvant Durvalumab or Placebo in Patients with Resectable Gastric and Gastroesophageal Cancer (GC/GEJC) (MATTERHORN).
Conditions Studied
Interventions
- DRUG Durvalumab
- DRUG FLOT chemotherapy
Study Locations (20)
California
- Research Site — Duarte
- Research Site — Los Angeles
- Research Site — Los Angeles
- Research Site — Sylmar
Other
- Research Site — Buenos Aires
- Research Site — Ciudad Autonoma Buenos Aires
- Research Site — Ciudad de Buenos Aires
- Research Site — Ciudad de Buenos Aires
Florida
- Research Site — St. Petersburg
- Research Site — Tallahassee
- Research Site — West Palm Beach
New York
- Research Site — New York
- Research Site — Rochester
Texas
- Research Site — Dallas
- Research Site — Lancaster
Indiana
- Research Site — Fort Wayne
Kentucky
- Research Site — Louisville
Massachusetts
- Research Site — Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 957 participants |
| Start Date | 2020-11-17 |
| Est. Completion | 2027-09-27 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04592913
The ClinicalTrials.gov registry entry for NCT04592913 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 957 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Gastrointestinal Neoplasms appearing as the primary indexed condition, and to 2 interventions — of which Durvalumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04592913 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Other, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04592913 about?
NCT04592913 is a clinical study titled "Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer". This is a Global Study of Neoadjuvant-Adjuvant Durvalumab or Placebo and FLOT Chemotherapy Followed by Adjuvant Durvalumab or Placebo in Patients with Resectable Gastric and Gastroesophageal Cancer (GC/GEJC) (MATTERHORN).
What is the current status of trial NCT04592913?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 957 participants. The study started on 2020-11-17. Estimated completion is 2027-09-27.
What conditions does trial NCT04592913 study?
This clinical trial studies the following conditions: Gastrointestinal Neoplasms, Esophagogastric Junction. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04592913?
The interventions under investigation include: Durvalumab (DRUG), FLOT chemotherapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04592913?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04592913 being conducted?
This trial has 20 study locations across California, Florida, Indiana, Kentucky, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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