Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04587115 · ClinicalTrials.gov registry record · Early Phase 1
Reducing the Abuse Liability of Prescription Opioids
A Early Phase 1 study of Addiction, sponsored by The University of Texas Health Science Center at San Antonio.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT04587115: Completed Early Phase 1 study of Addiction, sponsored by The University of Texas Health Science Center at San Antonio.
NCT04587115 is a Early Phase 1 study of Addiction that has completed, run by The University of Texas Health Science Center at San Antonio. The registered enrollment target is 15 participants, below the 692-participant average among 16 other Addiction trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04587115, a Early Phase 1 study of Addiction, has completed, sponsored by The University of Texas Health Science Center at San Antonio.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
Opioid (commonly called narcotic) pain medicines are, after marijuana, the most commonly abused substances in the United States. Patients who take opioids for legitimate reasons may become addicted; for example, as many as 1 in 4 patients meet the criteria for current opioid dependence. It is very important that a way is found to provide pain relief while minimizing the addiction potential of these widely used pain medications. The study aim to find out if the use of another type of medication given in addition to an opioid will reduce the addiction potential of the opioid. The study is trying to find out if the ability of the opioid to relieve pain is changed when given with the other medication, and to see if the euphoric sensation or "liking" of the opioid pain medication is reduced when taken with the other medication.
Primary Outcome
Perform quantitative evaluations of the analgesic efficacy of a novel fixed dose combination (FDC) of an opioid (oxycodone) in combination with one of two atypical antipsychotic drugs (either risperidone or ziprasidone) compared to the opioid alone. Analgesic efficacy will be measured with the cold pressor task which measures thermal pain. The cold pressor task measures the time the participant can tolerate their hand being submerged in the cold water up to a maximum of 5 minutes.
Conditions Studied
Interventions
- DRUG Risperidone
- DRUG Oxycodone
- DRUG Ziprasidone
Study Locations (1)
Texas
- Westgate Pain Clinic - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2017-06-16 |
| Est. Completion | 2020-01-01 |
| Phase | Early Phase 1 |
What the finished NCT04587115 record still lists
NCT04587115 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 692-participant average among 16 other Addiction trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Addiction appearing as the primary indexed condition, and to 3 interventions - of which Risperidone is the first listed.
NCT04587115 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04587115 about?
NCT04587115 is a clinical study titled "Reducing the Abuse Liability of Prescription Opioids". Opioid (commonly called narcotic) pain medicines are, after marijuana, the most commonly abused substances in the United States. Patients who take opioids for legitimate reasons may become addicted; for example, as many as 1 in 4 patients meet the criteria for current opioid dependence. It is very i...
What is the current status of trial NCT04587115?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 15 participants. The study started on 2017-06-16. Estimated completion is 2020-01-01.
What conditions does trial NCT04587115 study?
This clinical trial studies the following conditions: Addiction.
What interventions are being tested in trial NCT04587115?
The interventions under investigation include: Risperidone (DRUG), Oxycodone (DRUG), Ziprasidone (DRUG).
Who is sponsoring clinical trial NCT04587115?
This trial is sponsored by The University of Texas Health Science Center at San Antonio, which has 378 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04587115 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Addiction
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04587115's enrollment target sits among peer trials
15 14th of 16 higher than 2 of 16 other Addiction trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Addiction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Safety and Tolerability of Cannabidiol Among Persons With Opioid Use Disorder Receiving Methadone or Buprenorphine
COMPLETED · Early Phase 1
-
Semaglutide Therapy for Alcohol Reduction (STAR)
RECRUITING · Phase 2
-
Tdcs And cogNitive traininG cOmbined for AUD (TANGO)
RECRUITING · NA
-
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
RECRUITING
-
Behavioral and Functional Task Development, Implementation, and Testing
RECRUITING · NA
-
Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01889381 · 15 participants · Phase 2
Human Craniomaxillofacial Allotransplantation
- NCT02530073 · 15 participants · NA
Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) for CDH
- NCT02535936 · 15 participants · NA
Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
- NCT02918474 · 15 participants · NA
Decision Making Tool in Supporting Decision Making in Contralateral Prophylactic Mastectomy in Patients With Newly Diagnosed Breast Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI