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NCT04586452 · ClinicalTrials.gov registry record · Early Phase 1
NIH CCR2 AAA Study
A Early Phase 1 study of Abdominal Aortic Aneurysm (AAA) and No Abdominal Aortic Aneurysm (Non-AAA), sponsored by Washington University School of Medicine.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT04586452 is a Early Phase 1 study of Abdominal Aortic Aneurysm (AAA) and No Abdominal Aortic Aneurysm (Non-AAA) that has completed, run by Washington University School of Medicine. The registered enrollment target is 50 participants, below the 172-participant average among 3 other Abdominal Aortic Aneurysm (AAA) trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04586452, a Early Phase 1 study of Abdominal Aortic Aneurysm (AAA) and No Abdominal Aortic Aneurysm (Non-AAA), has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease, which is typically asymptomatic until rupture, resulting in high mortality. AAAs are more prevalent in men over age 65, though rupture is disproportionately higher in women. Due to nonlinear and unpredictable aortic dilatation, it is challenging to predict the AAA rupture using clinical diagnostics based on morphology. No medical therapy is used clinically to treat AAA, and there is an unmet need for clinically translatable, molecular biomarkers of AAA disease activity for surveillance and patient-specific management. The goal of this proposal is to develop a new approach for the diagnosis and targeted therapy of AAA.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST AAA Group (Aim 3A)
- DIAGNOSTIC_TEST Non-AAA Group
- OTHER Ex Vivo Human AAA Specimens (Aim 2A)
- OTHER Relationship between radiotracer and CCR2 (Aim 2B)
- DIAGNOSTIC_TEST AAA Group (Aim 3B-Reproducibility)
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2021-02-17 |
| Est. Completion | 2022-04-04 |
| Phase | Early Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04586452
The ClinicalTrials.gov registry entry for NCT04586452 describes a study currently listed as completed, categorized as Early Phase 1. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 172-participant average among 3 other Abdominal Aortic Aneurysm (AAA) trials with a reported enrollment target (71% lower). The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Abdominal Aortic Aneurysm (AAA) appearing as the primary indexed condition, and to 5 interventions - of which AAA Group (Aim 3A) is the first listed.
NCT04586452 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT04586452 about?
NCT04586452 is a clinical study titled "NIH CCR2 AAA Study". Abdominal aortic aneurysm (AAA) is a degenerative vascular disease, which is typically asymptomatic until rupture, resulting in high mortality. AAAs are more prevalent in men over age 65, though rupture is disproportionately higher in women. Due to nonlinear and unpredictable aortic dilatation, it i...
What is the current status of trial NCT04586452?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 50 participants. The study started on 2021-02-17. Estimated completion is 2022-04-04.
What conditions does trial NCT04586452 study?
This clinical trial studies the following conditions: Abdominal Aortic Aneurysm (AAA), No Abdominal Aortic Aneurysm (Non-AAA).
What interventions are being tested in trial NCT04586452?
The interventions under investigation include: AAA Group (Aim 3A) (DIAGNOSTIC_TEST), Non-AAA Group (DIAGNOSTIC_TEST), Ex Vivo Human AAA Specimens (Aim 2A) (OTHER), Relationship between radiotracer and CCR2 (Aim 2B) (OTHER), AAA Group (Aim 3B-Reproducibility) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04586452?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04586452 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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