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NIH CCR2 AAA Study
NCT04586452 · View on ClinicalTrials.gov ↗
Study Summary
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease, which is typically asymptomatic until rupture, resulting in high mortality. AAAs are more prevalent in men over age 65, though rupture is disproportionately higher in women. Due to nonlinear and unpredictable aortic dilatation, it is challenging to predict the AAA rupture using clinical diagnostics based on morphology. No medical therapy is used clinically to treat AAA, and there is an unmet need for clinically translatable, molecular biomarkers of AAA disease activity for surveillance and patient-specific management. The goal of this proposal is to develop a new approach for the diagnosis and targeted therapy of AAA.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST AAA Group (Aim 3A)
- DIAGNOSTIC_TEST Non-AAA Group
- OTHER Ex Vivo Human AAA Specimens (Aim 2A)
- OTHER Relationship between radiotracer and CCR2 (Aim 2B)
- DIAGNOSTIC_TEST AAA Group (Aim 3B-Reproducibility)
Study Locations (1)
Missouri
- Washington University School of Medicine — St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2021-02-17 |
| Est. Completion | 2022-04-04 |
| Phase | Early Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04586452
The ClinicalTrials.gov registry entry for NCT04586452 describes a study currently listed as completed. It is categorized as Early Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,036 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Abdominal Aortic Aneurysm (AAA) appearing as the primary indexed condition, and to 5 interventions — of which AAA Group (Aim 3A) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04586452 reports 1 study location spanning 1 distinct geographic area — top geographies include Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04586452 about?
NCT04586452 is a clinical study titled "NIH CCR2 AAA Study". Abdominal aortic aneurysm (AAA) is a degenerative vascular disease, which is typically asymptomatic until rupture, resulting in high mortality. AAAs are more prevalent in men over age 65, though rupture is disproportionately higher in women. Due to nonlinear and unpredictable aortic dilatation, it i...
What is the current status of trial NCT04586452?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 50 participants. The study started on 2021-02-17. Estimated completion is 2022-04-04.
What conditions does trial NCT04586452 study?
This clinical trial studies the following conditions: Abdominal Aortic Aneurysm (AAA), No Abdominal Aortic Aneurysm (Non-AAA). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04586452?
The interventions under investigation include: AAA Group (Aim 3A) (DIAGNOSTIC_TEST), Non-AAA Group (DIAGNOSTIC_TEST), Ex Vivo Human AAA Specimens (Aim 2A) (OTHER), Relationship between radiotracer and CCR2 (Aim 2B) (OTHER), AAA Group (Aim 3B-Reproducibility) (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04586452?
This trial is sponsored by Washington University School of Medicine, which has 1,036 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04586452 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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