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NCT04575740 · ClinicalTrials.gov registry record · NA
Phenotyping Mechanistic Pathways for Adverse Health Outcomes in Sleep Apnea
A NA study, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- NA
- Development phase
- 209
- Enrollment target
NCT04575740 is a NA study that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 209 participants.
The verdict
NCT04575740, a NA study, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 209 participants
- Enrollment target
Study Summary
Obstructive sleep apnea (OSA) is a highly prevalent disorder with adverse neurocognitive and cardio-metabolic outcomes. Continuous positive airway pressure (CPAP) is the gold standard therapeutic option to treat airway obstructions during sleep and thus, prevent its adverse cardiovascular and neurocognitive outcomes. Previous clinical trials, however, have largely failed to show a consistent impact of CPAP on these health outcomes. One of the main limitations of these trials may be the inadequate characterization of OSA and its acute physiological consequences. By characterizing OSA based on the "apnea-hypopnea index (AHI)", there is a potential risk of negative results. In this trial, the investigators intend to tackle this issue, by better characterization of OSA-related physiological consequences during sleep using physiologically driven metrics to capture the burden of OSA-related hypoxemia ("hypoxic burden"), autonomic response ("heart rate burden"), and sleep fragmentation ("arousal burden").
Interventions
- DEVICE PAP
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 209 participants |
| Start Date | 2020-09-10 |
| Est. Completion | 2025-09-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04575740
The ClinicalTrials.gov registry entry for NCT04575740 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 209 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which PAP is the first listed.
NCT04575740 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04575740 about?
NCT04575740 is a clinical study titled "Phenotyping Mechanistic Pathways for Adverse Health Outcomes in Sleep Apnea". Obstructive sleep apnea (OSA) is a highly prevalent disorder with adverse neurocognitive and cardio-metabolic outcomes. Continuous positive airway pressure (CPAP) is the gold standard therapeutic option to treat airway obstructions during sleep and thus, prevent its adverse cardiovascular and neuroc...
What is the current status of trial NCT04575740?
This trial is currently completed. It is a NA study. The enrollment target is 209 participants. The study started on 2020-09-10. Estimated completion is 2025-09-30.
What interventions are being tested in trial NCT04575740?
The interventions under investigation include: PAP (DEVICE).
Who is sponsoring clinical trial NCT04575740?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
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