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NCT04575727 · ClinicalTrials.gov registry record · Early Phase 1
Exploratory Evaluation of [11C]MPC6827
A Early Phase 1 study, sponsored by Columbia University.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 17
- Enrollment target
NCT04575727: Completed Early Phase 1 study, sponsored by Columbia University.
NCT04575727 is a Early Phase 1 study that has completed, run by Columbia University. The registered enrollment target is 17 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (68% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04575727, a Early Phase 1 study, has completed, sponsored by Columbia University.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 17 participants
- Enrollment target
Study Summary
This is a phase 0 study that will enable an assessment of biodistribution and estimation of absorbed dose in humans based on data collected from five healthy volunteers, which is typically the minimum number required by the FDA for first-in-human studies to assess dosimetry of a new tracer. The evaluation of the brain imaging of thirty additional subjects in the 2nd part of the study will lead to a descriptive assessment of the targeting and pharmacokinetics of MPC6827 in the brain and between normal and diseased brain.
Primary Outcome
Total body residence time and visual examination of whole body PET/CT images will be used to determine biodistribution of \[11C\]MPC6827.
Interventions
- DRUG [11C]MPC6827
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2021-01-08 |
| Est. Completion | 2024-06-21 |
| Phase | Early Phase 1 |
What the finished NCT04575727 record still lists
NCT04575727 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (68% lower).
The record links to 0 conditions, and to 1 intervention - of which [11C]MPC6827 is the first listed.
NCT04575727 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04575727 about?
NCT04575727 is a clinical study titled "Exploratory Evaluation of [11C]MPC6827". This is a phase 0 study that will enable an assessment of biodistribution and estimation of absorbed dose in humans based on data collected from five healthy volunteers, which is typically the minimum number required by the FDA for first-in-human studies to assess dosimetry of a new tracer. The eval...
What is the current status of trial NCT04575727?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 17 participants. The study started on 2021-01-08. Estimated completion is 2024-06-21.
What interventions are being tested in trial NCT04575727?
The interventions under investigation include: [11C]MPC6827 (DRUG).
Who is sponsoring clinical trial NCT04575727?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04575727's enrollment target sits among peer trials
17 1351st of 2000 higher than 632 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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