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NCT04572100 · ClinicalTrials.gov registry record · Phase 1
Pilot Study of Chemotherapy for HPV-Associated Oropharyngeal Cancer
A Phase 1 study, sponsored by University of Chicago.
- Completed
- Registry status
- Phase 1
- Development phase
- 50
- Enrollment target
NCT04572100: Completed Phase 1 study, sponsored by University of Chicago.
NCT04572100 is a Phase 1 study that has completed, run by University of Chicago. The registered enrollment target is 50 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04572100, a Phase 1 study, has completed, sponsored by University of Chicago.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 50 participants
- Enrollment target
Study Summary
Doctors leading this study will give blood tests to head and neck cancer participants during the beginning of chemotherapy treatment (also known as induction therapy) to see if these blood tests can help predict tumor shrinkage after therapy and reduce the amount of additional radiotherapy or chemotherapy treatment the participant may need. This study will also examine ways to reduce overall side effects of treatment using robotic surgery, chemotherapy and radiotherapy, or radiotherapy alone.
Primary Outcome
To determine if it is possible (feasibility) to measure HPV-DNA using blood tests among participants undergoing induction chemotherapy followed by a second round of response-based therapy for their HPV-associated cancer. This feasibility will be determined by measuring the proportion of patients who complete chemotherapy treatment and HPV-DNA assessments.
Interventions
- DRUG Carboplatin
- DRUG Paclitaxel
- OTHER Transoral Robotic Surgery (TORS) or Radiotherapy
- OTHER Chemotherapy and Low-Dose Radiotherapy
- OTHER Chemotherapy and High-Dose Radiotherapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2020-10-01 |
| Est. Completion | 2023-01-09 |
| Phase | Phase 1 |
What the finished NCT04572100 record still lists
NCT04572100 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% lower).
The record links to 0 conditions, and to 5 interventions - of which Carboplatin is the first listed.
NCT04572100 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04572100 about?
NCT04572100 is a clinical study titled "Pilot Study of Chemotherapy for HPV-Associated Oropharyngeal Cancer". Doctors leading this study will give blood tests to head and neck cancer participants during the beginning of chemotherapy treatment (also known as induction therapy) to see if these blood tests can help predict tumor shrinkage after therapy and reduce the amount of additional radiotherapy or chemot...
What is the current status of trial NCT04572100?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2020-10-01. Estimated completion is 2023-01-09.
What interventions are being tested in trial NCT04572100?
The interventions under investigation include: Carboplatin (DRUG), Paclitaxel (DRUG), Transoral Robotic Surgery (TORS) or Radiotherapy (OTHER), Chemotherapy and Low-Dose Radiotherapy (OTHER), Chemotherapy and High-Dose Radiotherapy (OTHER).
Who is sponsoring clinical trial NCT04572100?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04572100's enrollment target sits among peer trials
50 973rd of 2000 higher than 984 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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