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NCT04473781 · ClinicalTrials.gov registry record · Phase 1
Interstitial Brachytherapy for the Treatment of Unresectable/Unablatable Kidney Cancer
A Phase 1 study of Stage II Renal Cell Cancer and Stage I Renal Cell Cancer, sponsored by Jonsson Comprehensive Cancer Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 17
- Enrollment target
- 1
- Study location
NCT04473781: Recruiting Phase 1 study of Stage II Renal Cell Cancer and Stage I Renal Cell Cancer, sponsored by Jonsson Comprehensive Cancer Center.
NCT04473781 is a Phase 1 study of Stage II Renal Cell Cancer and Stage I Renal Cell Cancer that is actively recruiting participants, run by Jonsson Comprehensive Cancer Center. The registered enrollment target is 17 participants, below the 111-participant average among 4 other Stage II Renal Cell Cancer trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04473781, a Phase 1 study of Stage II Renal Cell Cancer and Stage I Renal Cell Cancer, is actively recruiting participants, sponsored by Jonsson Comprehensive Cancer Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 17 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase I/II trial investigates the side effects of interstitial brachytherapy and to see how well it works in limiting the growth of large kidney cancer masses in patients with kidney cancer that have refused or are unable to undergo surgery or ablation (unresectable/unablatable). Brachytherapy, also known as internal radiation therapy, temporarily introduces a radiation source into or near the tumor to eradicate the tumor cells. Giving brachytherapy may potentially reduce the size of the kidney cancer mass that would otherwise not be amenable to surgical management and translate into lower risk of spread.
Primary Outcome
A 3+3 safety lead-in phase will be employed in order to determine the DLT for interstitial renal brachytherapy. Grading of DLTs will follow the guidelines provided in the Common Terminology Criteria for Adverse Events version 5.0 criteria.
Conditions Studied
Interventions
- PROCEDURE Interstitial Radiation Therapy
Study Locations (1)
California
- UCLA / Jonsson Comprehensive Cancer Center - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2020-07-16 |
| Est. Completion | 2027-06-30 |
| Phase | Phase 1 |
What NCT04473781 shows while recruiting
NCT04473781 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 111-participant average among 4 other Stage II Renal Cell Cancer trials with a reported enrollment target (85% lower).
The record links to 2 conditions, with Stage II Renal Cell Cancer appearing as the primary indexed condition, and to 1 intervention - of which Interstitial Radiation Therapy is the first listed.
NCT04473781 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04473781 about?
NCT04473781 is a clinical study titled "Interstitial Brachytherapy for the Treatment of Unresectable/Unablatable Kidney Cancer". This phase I/II trial investigates the side effects of interstitial brachytherapy and to see how well it works in limiting the growth of large kidney cancer masses in patients with kidney cancer that have refused or are unable to undergo surgery or ablation (unresectable/unablatable). Brachytherapy,...
What is the current status of trial NCT04473781?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 17 participants. The study started on 2020-07-16. Estimated completion is 2027-06-30.
What conditions does trial NCT04473781 study?
This clinical trial studies the following conditions: Stage II Renal Cell Cancer, Stage I Renal Cell Cancer.
What interventions are being tested in trial NCT04473781?
The interventions under investigation include: Interstitial Radiation Therapy (PROCEDURE).
Who is sponsoring clinical trial NCT04473781?
This trial is sponsored by Jonsson Comprehensive Cancer Center, which has 321 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04473781 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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