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NCT04429685 · ClinicalTrials.gov registry record · Phase 1
The Effects of Low Dose Ketamine on Cardiovascular Function
A Phase 1 study, sponsored by University of Texas Southwestern Medical Center.
- Terminated
- Registry status
- Phase 1
- Development phase
- 6
- Enrollment target
NCT04429685: Clinical Trial Phase 1 study, sponsored by University of Texas Southwestern Medical Center.
NCT04429685 is a Phase 1 study that was terminated before completion, run by University of Texas Southwestern Medical Center. The registered enrollment target is 6 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04429685, a Phase 1 study, was terminated before completion, sponsored by University of Texas Southwestern Medical Center.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 6 participants
- Enrollment target
Study Summary
Low dose ketamine is used for pain management and for the treatment of anxiety and depression. Prior studies on low dose ketamine have noted short-term (minutes to hours) increases or decreases in blood pressure. Blood pressure that is too high or too low can be problematic if untreated. It is unknown exactly how low dose ketamine affects blood pressure. In fact, no prior studies have measured sympathetic nervous system activity after low dose ketamine has been given to an adult. Because sympathetic nervous system activity has a large influence on blood pressure, we need to know how exactly low dose ketamine affects these body systems. Therefore, in this research we will study how low dose ketamine affects sympathetic nervous system activity and cardiovascular function. The results from this research will inform doctors about how low dose ketamine affects the sympathetic nervous system, heart, and blood vessels.
Primary Outcome
We will measure muscle sympathetic nerve activity (MSNA), quantified as burst frequency and/or incidence, using microneurography
Interventions
- DRUG Ketamine
- DRUG Saline (placebo)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2020-11-01 |
| Est. Completion | 2021-05-28 |
| Phase | Phase 1 |
Why NCT04429685 stopped before completion
NCT04429685 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% lower).
The record links to 0 conditions, and to 2 interventions - of which Ketamine is the first listed.
NCT04429685 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04429685 about?
NCT04429685 is a clinical study titled "The Effects of Low Dose Ketamine on Cardiovascular Function". Low dose ketamine is used for pain management and for the treatment of anxiety and depression. Prior studies on low dose ketamine have noted short-term (minutes to hours) increases or decreases in blood pressure. Blood pressure that is too high or too low can be problematic if untreated. It is unkno...
What is the current status of trial NCT04429685?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 6 participants. The study started on 2020-11-01. Estimated completion is 2021-05-28.
What interventions are being tested in trial NCT04429685?
The interventions under investigation include: Ketamine (DRUG), Saline (placebo) (DRUG).
Who is sponsoring clinical trial NCT04429685?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04429685's enrollment target sits among peer trials
6 1974th of 2000 higher than 12 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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