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NCT04423627 · ClinicalTrials.gov registry record · Early Phase 1
Sympathetic Regulation of Large Artery Stiffness in Humans With ISH
A Early Phase 1 study, sponsored by University of Iowa.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 100
- Enrollment target
NCT04423627: Completed Early Phase 1 study, sponsored by University of Iowa.
NCT04423627 is a Early Phase 1 study that has completed, run by University of Iowa. The registered enrollment target is 100 participants, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (89% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04423627, a Early Phase 1 study, has completed, sponsored by University of Iowa.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 100 participants
- Enrollment target
Study Summary
Stiffening of your blood vessels, particularly the large vessels from your heart (called the aorta and carotids) you age contributes to the development of cardiovascular disease (CVD) such as heart attack and stroke. Nerve activity from your brain to your body also increases with advancing age but it is unknown if this nerve activity contributes directly to the stiffening on your blood vessels in older adults in addition to high blood pressure. Therefore, successful completion of the proposed aims will have a significant clinical impact by identifying if nerve activity from your brain could be a novel target for therapies that would lower stiffness of the aorta and carotid arteries in older adults.
Primary Outcome
Aortic stiffness
Interventions
- DRUG Placebo
- DRUG Clonidine
- DRUG Hydrochlorothiazide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2021-06-01 |
| Est. Completion | 2025-07-31 |
| Phase | Early Phase 1 |
What the finished NCT04423627 record still lists
NCT04423627 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (89% higher).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT04423627 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04423627 about?
NCT04423627 is a clinical study titled "Sympathetic Regulation of Large Artery Stiffness in Humans With ISH". Stiffening of your blood vessels, particularly the large vessels from your heart (called the aorta and carotids) you age contributes to the development of cardiovascular disease (CVD) such as heart attack and stroke. Nerve activity from your brain to your body also increases with advancing age but i...
What is the current status of trial NCT04423627?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 100 participants. The study started on 2021-06-01. Estimated completion is 2025-07-31.
What interventions are being tested in trial NCT04423627?
The interventions under investigation include: Placebo (DRUG), Clonidine (DRUG), Hydrochlorothiazide (DRUG).
Who is sponsoring clinical trial NCT04423627?
This trial is sponsored by University of Iowa, which has 228 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04423627's enrollment target sits among peer trials
100 184th of 2000 higher than 1,783 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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