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NCT04402294 · ClinicalTrials.gov registry record · NA
Individualized Closed Loop TMS for Working Memory Enhancement
A NA study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- NA
- Development phase
- 27
- Enrollment target
NCT04402294: Completed NA study, sponsored by University of Pennsylvania.
NCT04402294 is a NA study that has completed, run by University of Pennsylvania. The registered enrollment target is 27 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04402294, a NA study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- NA
- Development phase
- 27 participants
- Enrollment target
Study Summary
The study is investigating working memory brain states by using transcranial magnetic stimulation (TMS) in combination with functional magnetic resonance imaging (fMRI). The study uses a novel, individualized targeting approach for TMS based on each subject's individual multi-modal fMRI data. The individualized target will be stimulated in a TMS/ fMRI imaging session to investigate working memory states and optimal stimulation frequencies.
Primary Outcome
During the TMS/fMRI scan, participants perform a working memory task (N-back). To evaluate how different repetitive TMS frequencies (5, 10, and 20 Hz) impact reaction time during N-back task, each rTMS train is followed by a block of the N-back task. A decoder identifies one frequency as optimal frequency and another as suboptimal frequency. Reaction Time during optimal, suboptimal, and no stimulation condition is assessed by taking average of reaction time on accurate trials with faster reactio
Interventions
- DEVICE Repetitive Transcranial Magnetic Stimulation (rTMS)
- DIAGNOSTIC_TEST Functional Magnetic Resonance Imaging (fMRI)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2021-11-24 |
| Est. Completion | 2024-06-13 |
| Phase | NA |
What the finished NCT04402294 record still lists
NCT04402294 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Repetitive Transcranial Magnetic Stimulation (rTMS) is the first listed.
NCT04402294 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04402294 about?
NCT04402294 is a clinical study titled "Individualized Closed Loop TMS for Working Memory Enhancement". The study is investigating working memory brain states by using transcranial magnetic stimulation (TMS) in combination with functional magnetic resonance imaging (fMRI). The study uses a novel, individualized targeting approach for TMS based on each subject's individual multi-modal fMRI data. The in...
What is the current status of trial NCT04402294?
This trial is currently completed. It is a NA study. The enrollment target is 27 participants. The study started on 2021-11-24. Estimated completion is 2024-06-13.
What interventions are being tested in trial NCT04402294?
The interventions under investigation include: Repetitive Transcranial Magnetic Stimulation (rTMS) (DEVICE), Functional Magnetic Resonance Imaging (fMRI) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04402294?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04402294's enrollment target sits among peer trials
27 1708th of 2000 higher than 291 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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